黄精多糖的结构分析及功能活性研究进展

黄精是一种传统的药食同源类中药,具有补气养阴、健脾、润肺、益肾等功能,主要含有多糖、甾体皂苷、蒽醌类化合物、生物碱、强心苷、木质素、维生素等化合物,而黄精多糖是黄精的主要活性成分。近年来,黄精多糖的组成结构分析及其功能活性的研究取得了很大的进展,本文通过查阅国内外相关文献,对黄精多糖的主要化学组成及其分子量测定、结构分析及功能活性进行系统的归纳,结果显示黄精多糖的化学组成主要有阿拉伯糖、半乳糖、葡萄糖、甘露糖、果糖和半乳糖醛酸,以及少量的木糖和葡萄糖醛酸;在药理活性方面,其具有一定的抗肿瘤、抗氧化与抗衰老、提高免疫力、调节血糖血脂、抗菌抗炎及调节细胞内分泌等作用,具有广泛的应用价值及市场前景。但是,缺少黄精多糖化学组成及其体内、体外生物学作用及机制的研究,因此,本文将对其应用前景进行讨论与展望,提出进一步的研究方向,为其保健品的开发及疾病的治疗提供理论依据。

Structural Analysis and Functional Activity Research Progress of Polygonatum Sibiricum Polysaccharides

Polygonatum sibiricum is a traditional Chinese medicine of drug Edible, with many functions of tonifying qi and nourishing yin, strengthening spleen and kidney, moistening lung and so on. It mainly contains polysaccharides, steroidal saponins, anthraquinones, alkaloids, cardiac glycosides, lignin, vitamins and other compounds, and polysaccharide is the main of them. In recent years, the study of composition structure analysis and functional activity of Polygonatum sibiricum polysaccharides (PSP )has made great progress. In this paper, the relevant research of the main chemical composition and molecular weight determination,the structure analysis and functional activity of PSP were systematically summarized by referring to retrieve related documents, the results showed the chemical composed of PSP mainly included arabinose, galactose, glucose, mannose, fructose and galacturonic acid, and small amounts of xylose and glucuronic acid, in terms of pharmacological activity, it has certain anti-tumor antioxidant and anti-aging, enhancing immunity, regulating blood glucose and lipid, anti-inflammatory and regulating cell endocrine effects, and broad application and market prospects. However, the lack of research about PSP chemical composition and biological effects and mechanisms in vivo or vitro, therefore, this article will discuss with the prospect of its application prospects and proposing further research, provide the theoretical basis of health care products and treatment of disease.