| VEGF基因多态性与子宫内膜异位症发病风险的相关性研究 |
| |
| 引用本文： | 刘青,张华,李琰,康山. VEGF基因多态性与子宫内膜异位症发病风险的相关性研究[J]. 中国优生与遗传杂志, 2010, 0(4): 29-32,16 |
| |
| 作者姓名： | 刘青 张华 李琰 康山 |
| |
| 作者单位： | 首都医科大学附属北京佑安医院妇产科;河北省肿瘤研究所分子生物学教研室;河北医科大学第四医院妇产科; |
| |
| 摘 要： | 目的探讨血管内皮生长因子（vascular endothelial growth factor,VEGF）-460C/T、-1154G/A、-2578C/A和＋936C/T单核苷酸多态性与子宫内膜异位症的关系。方法采用PCR-RFLP方法检测344例子宫内膜异位症患者（病例组）和360名对照妇女（对照组）的VEGF基因多态性位点的基因型频率分布情况。结果VEGF-460C/T和＋936C/T多态的基因型和等位基因频率分布在病例组与对照组间差异均无统计学意义（P〉0.05）。在病例组和对照组中,VEGF-1154G/A和VEGF-2578C/A多态的基因型及等位基因频率分布差异均有统计学意义（P〈0.05）;与GA＋AA/AA＋CA基因型相比,携带GG/CC基因型明显增加内异症的发病风险（OR=1.43,95%CI：1.05～1.96）/（OR=1.47,95%CI：1.09～2.00）。VEGF-460C/T、-1154G/A、-2578C/A多态的单倍型频率在病例组和对照组间差异有统计学意义（P=0.000）。结论1.携带VEGF-1154GG和-2578CC基因型显著增加子宫内膜异位症的发病风险;2.单倍型VEGF-460/-1154/-2578TGC,CAA,TAA和TAC与子宫内膜异位症的发病明显相关。
|
| 关 键 词： | 子宫内膜异位症 血管内皮生长因子 基因多态性 遗传易感性 |
Study on the association of SNPs of VEGF genes with the risk of endometriosis |
| |
| LIU Qing,KANG Shan,LI Yan,ZHANG Hua.. Study on the association of SNPs of VEGF genes with the risk of endometriosis[J]. Chinese Journal of Birth Health & Heredity, 2010, 0(4): 29-32,16 |
| |
| Authors: | LIU Qing KANG Shan LI Yan ZHANG Hua. |
| |
| Affiliation: | LIU Qing1,KANG Shan2,LI Yan3,ZHANG Hua1.(1.Department of Obstetrics , Gynecology,Affiliated Beijing Youan Hospital of Shoudou Medical University,Beijing,100853 P.R.China,2.Department of Obstetrics , Gynecology,the Fourth Affiliated Hospital of Hebei Medical University,Shijiazhuang,Hebei,050011 P.R.China,3.Department of Molecular Biology,Hebei Cancer Institute,050011 P.R.China) |
| |
| Abstract: | Objective:To investigate the association of single nucleotide polymorphisms (SNPs) in VEGF gene with the risk of endometriosis.Methods:Genotypes of VEGF were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method among 344 endometriosis patients,360 frequency-matched control women of endometriosis.Results:No significant difference was found in allele and genotype distributions of the -460C/T,+936C/T polymorphisms between patients and controls (all P value >0.05).How... |
| |
| Keywords: | Endometriosis VEGF Genetic polymorphism Susceptibility |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
