左氧氟沙星致过敏性休克临床特点分析

目的探讨左氧氟沙星致过敏性休克的临床特点,为临床正确诊断、处理及合理用药提供帮助。方法收集1994年1月-2008年6月CNKI全文数据库、万方数据库、中文科技期刊数据库和中文生物医学文献数据库中左氧氟沙星致过敏性休克病例,对患者一般资料、基础疾病、诊断、用药剂量、用药方式、合并用药、用药后发作的时间、首发症状、意识状态、血压、用药状况、恢复时间、是否使用呼吸机辅助通气、患者的转归等进行分析。结果共收集42例。引起过敏性休克均为静脉用药,34例患者于首次用药或首日用药后出现,占80.95%,发作时间数秒至60min。8例为24h～8d后出现。40例患者痊愈,恢复时间10min～24h,1例患者死亡,1例患者出现脑瘫。结论左氧氟沙星致过敏性休克存在速发和迟发,正确选择适应证、用药途径可减少其发生,多数可通过及时诊断和处理治愈。

Clinical characteristics of shock induced by levofloxacin

Objective To discuss the clinical characteristics of shock induced by levofloxacin in 42 patients.Methods The clinical data of shock induced by levofloxacin in 42 cases were collected from CBMdisc,CHDL and CNKI(1994-2008).Patients baseline diseases and diagnosis,dosage,administration route,drug combination,attack time,first symptoms,consciousness,blood pressure,treating drugs,recovery time,whether or not using ventilator and prognosis were analyzed.Results 42 cases were collected.All the shock patients were administrated intravenously.34 patients appeared shock in first using levofloxacin or in first day.The attack time was from several seconds to 60 min.8 patients occurred from 24 h to 8 d.40 patients recovered with recovery time 10 min~24 h,while a patient died,and a patient appeared cerebral palsy.Conclusion The allergic shock can be caused by levofloxacin,it should occurr immediately or late.Correct selection of indication and administration route could reduce it,and most of the patients could recover.