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Gangrene and renal failure caused by dihydroergotamine used to treat raised intracranial pressure following head trauma
Authors:V. L. Gupta, T. O. Mjø  rndal
Affiliation:Department of Anesthesiology and Intensive Care and Division of Clinical Pharmacology, UmeåUniversity Hospital, Umeå, Sweden
Abstract:
A case of peripheral gangrene and renal failure following the use of dihydroergotamine (DHE) for treatment of raised intracranial pressure (ICP) is reported. There have been several reports of vasospasm and peripheral gangrene caused by DHE used in combination with heparin for prevention of deep venous thrombosis. Clinical experience with the use of DHE in head trauma is limited. This case report emphasises the seriousness of the adverse effects associated with the use of this drug.
Keywords:Intracranial pressure    dihydroergotamine    gangrene    ischemia    kidney failure    spasm
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