冠心病及克山病患者血管紧张素转换酶活性变化观察

目的 探讨血管紧张素转换酶（ACE）活性变化在冠心病（CHD）及克山病（KSD）诊断和病情判断中的价值。方法 选择住院冠心病患者34例，克山病病区的克山病患者39例，健康人32例作为对照。用紫外分光光度法测定ACE活性。结果 冠心病及克山病患者ACE活性明显低（P＜0．01）于健康人。冠心病患者的ACE活性急性心梗＜心绞痛＜陈旧性心梗，在克山病是慢型＜潜在型。ACE活性降低可能与血管缺血缺氧有关。结论 ACE活性变化可作为冠心病及克山病诊断和病情判断的参考指标。

Observation of serum angiotensin converting enzyme activity in patie nts with coronary heart disease and Kenshan disease

Objective To explore the value of angiotensin converting enzyme (ACE) activity in diagnosis of coronary heart disease (CHD) and Keshan disease (KSD).Methods 34 patients with CHD and 39 patients with KSD (latent and chronic KSD)were chosen. At the same time health men were used as control group. ACE activities were measured in all subjects by Uv spectrophotometry. Results ACE activities were significantly lower in CHD and KSD groups than in control group.The ACE activity was lower among the patients with CHD and KSD. The ACE activity of acute myocardial infarction as the lowest among the patients with CHD. These changes may be related to blood vessel injury which was caused by lack of blood and oxygen of vessels when heart function was worse.Conclusions ACE activity changes may be used as the index for diagnosis and evaluating patient's condition of CHD and KSD.