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| 磁共振弥散加权成像动态监测肿瘤血管靶向治疗的疗效 | |
| 引用本文： | 邵海波,徐克,周玮,倪以成,戴旭,张健,陈峰,孙自平.磁共振弥散加权成像动态监测肿瘤血管靶向治疗的疗效[J].中国医学影像技术,2011,27(3):457-461. |
| 作者姓名： | 邵海波 徐克 周玮 倪以成 戴旭 张健 陈峰 孙自平 |
| 作者单位： | 1. 中国医科大学附属第一医院放射科,辽宁,沈阳,110001 2. 泰兴市人民医院放射科,江苏,泰兴,225400 3. 鲁汶大学医学院放射科,比利时,鲁汶,3000 4. 江苏省中医药研究院中药资源与化学研究室,江苏,南京,210028 5. 山东省医学科学院放射医学研究所,山东,济南,250062 |
| 基金项目： | 沈阳市科学技术项目(F10-205-1-19)、辽宁省教育厅重点实验室项目(2009S110)。 |
| 摘 要： | 目的 探讨磁共振DWI监测肿瘤血管靶向治疗后动态变化的可行性。方法 选取新西兰大白兔15只建立兔肌肉VX2肿瘤模型(共30个肿瘤)。分别于肿瘤血管靶向治疗(CA-4-P,20 mg/kg体质量)前及治疗后1、4、8、12天进行常规、增强MRI及DWI,比较相邻时间点肿瘤整体、肿瘤中心、周边及肌肉组织的ADC值动态变化,并与病理表现进行对照。结果 肿瘤血管靶向治疗前(MR基线扫描),肿瘤整体、肿瘤中心、周边及肌肉组织的ADC值分别为(1.33±0.16)×10－3 mm2/s、(1.30±0.23)×10－3 mm2/s、(1.19±0.31)×10－3 mm2/s及(1.66±0.13)×10－3 mm2/s;镜下见肿瘤细胞生长旺盛。治疗后1天,肿瘤中心ADC值较MR基线扫描减低(P＜0.05);镜下见肿瘤细胞肿胀,排列松散,靠近肿瘤中心处可见肿瘤细胞破裂、核固缩。治疗后4天,肿瘤整体、肿瘤中心及周边ADC值较治疗后1天增高(P均＜0.05);镜下可见大范围肿瘤坏死。治疗后8天,肿瘤中心ADC值较治疗后4天增高(P＜0.05);镜下见肿瘤中心坏死更加彻底。治疗后12天,肿瘤整体及肿瘤周边ADC值较治疗后8天减低(P均＜0.05);镜下可见肿瘤周边新生的肿瘤组织。结论 DWI能准确反映兔肌肉VX2肿瘤模型CA-4-P给药后肿瘤组织的动态变化,可作为理想的肿瘤血管靶向治疗监测和疗效评价手段。 |
| 关 键 词： | 肿瘤 分子靶向治疗 考布他汀A4 扩散磁共振成像 |
| 收稿时间： | 2010/10/10 0:00:00 |
| 修稿时间： | 2010/11/22 0:00:00 |
Diffusion-weighted imaging in dynamic monitoring the efficacy of tumor vascular targeting therapy |
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| SHAO Hai-bo,XU Ke,ZHOU Wei,NI Yi-cheng,DAI Xu,ZHANG Jian,CHEN Feng and SUN Zi-ping.Diffusion-weighted imaging in dynamic monitoring the efficacy of tumor vascular targeting therapy[J].Chinese Journal of Medical Imaging Technology,2011,27(3):457-461. | |
| Authors: | SHAO Hai-bo XU Ke ZHOU Wei NI Yi-cheng DAI Xu ZHANG Jian CHEN Feng and SUN Zi-ping |
| Institution: | Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;Department of Radiology, Taixing People's Hospital, Taixing 225400, China;Section of Radiology, Department of Medical Diagnostic Science, University of Leuven, Leuven 3000, Belgium;Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China;Staff Room of Plant Resources and Chemistry of Traditional Chinese Medicine, Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China;Department of Radiology, Taixing People's Hospital, Taixing 225400, China;Radiation Medical Institute, Shandong Academy of Medical Sciences, Jinan 250062, China |
| Abstract: | Objective To investigate the feasibility of DWI in monitoring the dynamic characteristics of tumors after vascular disrupting treatment.Methods Fifteen New Zealand white rabbits were selected,and the models of VX2 tumors in muscle(totally 30 lesions) were established.Conventional,enhanced MRI and DWI were performed before and 1,4,8,12 days after intravenous administration of combretastatin A4 phosphate(CA-4-P) with the dosage of 20 mg/kg.The dynamic changes of ADC value in entire,central,peripheral part of ... |
| Keywords: | Neoplasms Molecular targeted therapy Combretastatin A-4 Diffusion magnetic resonance imaging |
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