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补肾益气活血方对胎儿生长受限胎鼠IGF-1、IGFBP-1及IGFBP-3表达的影响
引用本文:王琪,熊丽萍,陶秀良. 补肾益气活血方对胎儿生长受限胎鼠IGF-1、IGFBP-1及IGFBP-3表达的影响[J]. 湖北中医药大学学报, 2011, 13(5): 6-9
作者姓名:王琪  熊丽萍  陶秀良
作者单位:华中科技大学附属同济医院中西医结合研究所;广州军区武汉总医院病理科;华中科技大学附属同济医院中西医结合科;
基金项目:国家自然科学基金资助项目“补肾益气活血方对IUGR相关基因及细胞信息传导的影响”(39870923)
摘    要:目的 观察补肾益气活血方对胎儿生长受限胎鼠肝脏IGF-1、IGFBP-1、IGFBP-3表达的影响,探讨补肾益气活血方治疗FGR的作用机制.方法 采用被动吸烟法建立SD大鼠FGR模型,分为正常组、FGR组、补肾益气活血方治疗组(中药组)、精氨酸治疗组(精氨酸组).采用免疫组织化学方法检测胎鼠肝脏IGF-1、IGFBP-...

关 键 词:胎儿生长受限  补肾益气活血方  胰岛素样生长因子-1  胰岛素样生长因子结合蛋白-1  胰岛素样生长因子结合蛋白-3

Effect of Reinforcing Kidney Replenishing qi and Promoting Blood Circulation Recipe on the Expression of IGF-1,IGFBP-1 and IGFBP-3 in liver of the Fetal Rat with FGR
WANG Qi,XIONG Liping,TAO Xiuliang. Effect of Reinforcing Kidney Replenishing qi and Promoting Blood Circulation Recipe on the Expression of IGF-1,IGFBP-1 and IGFBP-3 in liver of the Fetal Rat with FGR[J]. Journal of Hubei University of Chinese Medicine, 2011, 13(5): 6-9
Authors:WANG Qi  XIONG Liping  TAO Xiuliang
Affiliation:WANG Qi1,XIONG Liping2,TAO Xiuliang3 (1.Institute of Integrated Traditional Chinese Medicine and Western Medicine,Tongji Hospital Affiliated to Huazhong University of Science and Technology,Wuhan 430030,Hubei,P.R.China,2.Department of Pathology,Wuhan General Hospital of Guangzhou Military,Wuhan 430070,3.Department of Integrated Traditional Chinese Medicine and Western Medicine,P.R.China)
Abstract:Objective To investigate the effect of Bushen Yiqi Huoxue(Reinforcing Kidney Replenishing qi and Promoting Blood Circulation) Decoction on the expression of IGF-1,IGFBP-1 and IGFBP-3 proteins in fetal liver of Fetal growth restriction(FGR) rat.Methods The smoke inhalation rat model was created.Thirty two pregnant Sprague-Dawley rats were randomly dividedly into four groups: control group,FGR group,group of FGR treated with Bushen Yiqi Huoxue Decoction(Chinese medicine group),group of FGR treated with argini...
Keywords:Fetal growth restriction  Bushen Yiqi Huoxue Decoction  Insulin like growth factor-1  Insulin like growth factor binding protein-1  Insulin like growth factor binding protein-3  
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