| The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity? |
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| 引用本文： | Lloubès R,Cascales E,Walburger A,Bouveret E,Lazdunski C,Bernadac A,Journet L. The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity?[J]. Research in microbiology, 2001, 152(6): 523-529. DOI: 10.1016/S0923-2508(01)01226-8 |
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| 作者姓名： | Lloubès R Cascales E Walburger A Bouveret E Lazdunski C Bernadac A Journet L |
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| 摘 要： | ![]()
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| 收稿时间： | 2001-01-31 |
The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity? |
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| Lloubès R,Cascales E,Walburger A,Bouveret E,Lazdunski C,Bernadac A,Journet L. The Tol-Pal proteins of the Escherichia coli cell envelope: an energized system required for outer membrane integrity?[J]. Research in microbiology, 2001, 152(6): 523-529. DOI: 10.1016/S0923-2508(01)01226-8 |
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| Authors: | Lloubès R Cascales E Walburger A Bouveret E Lazdunski C Bernadac A Journet L |
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| Affiliation: | Institut de Biologie Structurale et Microbiologie (CNRS), UPR 9027, Marseille, France. lloubes@ibsm.cnrs-mrs.fr |
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| Abstract: | ![]()
The outer membrane of gram-negative bacteria acts as a barrier against harmful lipophilic compounds and larger molecules unable to diffuse freely through the porins. However, outer membrane proteins together with the Tol-Pal and TonB systems have been exploited for the entry of macromolecules such as bacteriocins and phage DNA through the Escherichia coli cell envelope. The TonB system is involved in the active transport of iron siderophores and vitamin B12, while no more precise physiological role of the Tol-Pal system has yet been defined than its requirement for cell envelope integrity. These two systems, containing an energized inner membrane protein interacting with outer membrane proteins, share similarities. |
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