Behavioral phenotypes of inbred mouse strains: implications and recommendations for molecular studies |
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| Authors: | J. N. Crawley John K. Belknap Allan Collins John C. Crabbe Wayne Frankel Norman Henderson Robert J. Hitzemann Stephen C. Maxson Lucinda L. Miner Alcino J. Silva Jeanne M. Wehner Anthony Wynshaw-Boris R. Paylor |
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| Affiliation: | (1) Section on Behavioral Neuropharmacology, Experimental Therapeutics Branch, National Institute of Mental Health, Building 10, Room 4D11, Bethesda, MD 20892-1375, USA, US;(2) Portland Alcohol Research Center, Department of Behavioral Neuroscience, Oregon Health Sciences University and VA Medical Center, Portland, OR 97201, USA, US;(3) Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80303, USA, US;(4) The Jackson Laboratory, Bar Harbor, ME 04609, USA, US;(5) Department of Psychology, Oberlin College, Oberlin, OH 44074-1086, USA, US;(6) Department of Psychiatry, State University of New York, Stony Brook, NY 11794–8101, USA, US;(7) Biobehavioral Sciences Graduate Degree Program and Department of Psychology, University of Connecticut, Storrs, CT 06269-4154, USA, US;(8) Molecular Neurobiology Laboratory, National Institute on Drug Abuse, Baltimore, MD 21224, USA, TP;(9) Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA, US;(10) Laboratory of Genetic Disease Research, National Institute, Human Genome Research Institute, Bethesda, MD 20892-4470, USA, US |
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| Abstract: | Choosing the best genetic strains of mice for developing a new knockout or transgenic mouse requires extensive knowledge of the endogenous traits of inbred strains. Background genes from the parental strains may interact with the mutated gene, in a manner which could severely compromise the interpretation of the mutant phenotype. The present overview summarizes the literature on a wide variety of behavioral traits for the 129, C57BL/6, DBA/2, and many other inbred strains of mice. Strain distributions are described for open field activity, learning and memory tasks, aggression, sexual and parental behaviors, acoustic startle and prepulse inhibition, and the behavioral actions of ethanol, nicotine, cocaine, opiates, antipsychotics, and anxiolytics. Using the referenced information, molecular geneticists can choose optimal parental strains of mice, and perhaps develop new embryonic stem cell progenitors, for new knockouts and transgenics to investigate gene function, and to serve as animal models in the development of novel therapeutics for human genetic diseases. Received: 8 November 1996 / Final version: 15 March 1997 |
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| Keywords: | Mouse Inbred strains Behavior Genetics Locomotion Open field activity Learning Memory Aggression Parental behaviors Acoustic startle Prepulse inhibition Alcohol Nicotine Cocaine Opiates Haloperidol Diazepam Breeding Embryonic stem cell lines Transgenic Knockouts Null mutation |
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