重性抑郁障碍首次发病患者记忆损害及其与血清皮质醇水平的关系

目的:探讨重性抑郁障碍首次发病患者记忆损害与血清皮质醇的关系。方法:对30例重性抑郁障碍首次发病患者和30名正常对照者进行韦氏记忆量表(WMS)测量以评定其记忆水平,同时进行血清皮质醇的浓度测定。结果:重性抑郁障碍组的韦氏记忆商数及心智、图片、再认、再生、联想、理解、背数因子分显著低于正常对照组﹙P0.01﹚;韦氏记忆因子中的心智、图片、再认、再生、联想、背数、理解、记忆商数与HAMD总分以及HAMD因子中的焦虑/躯体化、认识障碍、阻滞、睡眠障碍显著负相关(P0.05);血清皮质醇浓度与韦氏记忆因子中的心智、图片、再认、再生、联想、背数、记忆商数显著负相关(r分别=-0.432,-0.410,-0.399,-0.421,-0.472,-0.436,P0.05);重性抑郁障碍患者的韦氏记忆各因子得分与其年龄、病程存在负相关(P0.05)。结论:重性抑郁障碍首次发病患者急性期存在记忆功能减退,并与血清皮质醇浓度可能存在相关性。

Memory imPairment and its relationshiP with serum cortisol in the first ePisode of major dePressive dis-order

Objective：To explore the relationship between serum cortisol and memory impairment in first episode patients with major depressive disorder. Method：Thirty patients with first episode major depression and 30 healthy controls were measured by Wechsler memory scale（ WMS）to assess their memory levels and their serum cortisol levels were measured. Results：Wechsler memory quotient and factor mind,pictures,recognition,reproduction,association,comprehension and digit span of the depression group were significantly lower than the healthy group（P ﹤ 0. 01）;Wechsler memory factors including mind,pictures,recognition,reproduction, association,comprehension,digit span and memory quotient were significantly negatively correlated with HAMD total score and HAMD factor which included anxiety/ somatization,awareness barriers,blocking,sleep disorders （P ﹤ 0. 02）;There was significant negative correlation between serum cortisol concentrations and Wechsler memory factor including mind,pictures,recognition,reproduction,association,digit span and memory quotient （r = - 0. 432,- 0. 410,- 0. 399,- 0. 421,- 0. 472,- 0. 436,respectivelyP ﹤ 0. 02）;Wechsler Memory factor scores was significantly negatively correlated with age and disease duration（P ﹤ 0. 02）. Conclusion：The first episode patient with major depressive disorder shows memory deficiency;which may be correlated with serum cortisol levels.