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| 调节胆固醇代谢的新药物靶点LXR | |
| 引用本文： | 王璐,谢元翼,李雪,蔡怀涵,王小岩,刘旭东,宋青. 调节胆固醇代谢的新药物靶点LXR[J]. 中国现代药物应用, 2009, 3(15): 189-191 |
| 作者姓名： | 王璐 谢元翼 李雪 蔡怀涵 王小岩 刘旭东 宋青 |
| 作者单位： | 北京科技大学应用科学学院,100083 |
| 摘 要： | 本文对细胞核受体LXRs（Liver X Receptors）及其天然和人工合成配体的发现进行了系统简介，着重描述了部分激动剂的药理作用，及其作为胆固醇代谢调节因子在疾病动物模型上的初步验证。LXR选择性激动剂可以对动脉粥样硬化和老年痴呆症的延缓及预防起积极作用，有潜力成为临床治疗药品。 |
| 关 键 词： | 细胞核受体 LXRs 胆固醇 动脉粥样硬化 老年痴呆 |
New Drug Targets LXR for Cholesterol Control |
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| WANG Lu,XIE Yuan-Yi,LI Xue,CAI Huai-Han,WANG Xiao-Yan,LIU Xu-Dong,SONG Qing. New Drug Targets LXR for Cholesterol Control[J]. Chinese Journal of Modern Drug Application, 2009, 3(15): 189-191 | |
| Authors: | WANG Lu XIE Yuan-Yi LI Xue CAI Huai-Han WANG Xiao-Yan LIU Xu-Dong SONG Qing |
| Affiliation: | WANG Lu, XIE Yuan-Yi, LI Xue, CAI Huai-Han, WANG Xiao-Yan, LIU Xu-Dong,( SONG Ching College of Applied Science, University of Science and Technology Beijing, Beijing 100083, China) |
| Abstract: | This brief review summarizes the discovery and development of nuclear receptor LXRs （Liver X Receptors） and their naturally occurring or synthetic ligands, with an emphasis on the pharmacological effects of some agonists, especially their therapeutic value on model animals as cholesterol metabolism regulators. It seems plausible for LXR selective modulators to be developed into clinical agents against vascular atherosclerosis and Alzheimer＇s disease. |
| Keywords: | LXRs |
| 本文献已被 维普 万方数据 等数据库收录！ | |