首页 | 本学科首页   官方微博 | 高级检索  
     

宫内窘迫新生儿脐动脉血超氧化物歧化酶及丙二醛检测的临床意义
引用本文:Qin LN,Feng AH,Yang CH,Xing HY. 宫内窘迫新生儿脐动脉血超氧化物歧化酶及丙二醛检测的临床意义[J]. 中华妇产科杂志, 2005, 40(5): 312-314
作者姓名:Qin LN  Feng AH  Yang CH  Xing HY
作者单位:250031,济南市第四人民医院妇产科
摘    要:
目的 探讨脂质过氧化与胎儿窘迫,以及与新生儿缺血缺氧性脑病(HIE)的关系。方法 将产程中发生宫内窘迫的新生儿60例作为研究对象其中出生后无窒息者39例为检测Ⅰ组,有窒息者21例为检测Ⅱ组;取同期正常新生儿30例为对照组。检测各组新生儿脐动脉血超氧化物歧化酶(SOD)、丙二醛水平,观察各组新生儿HIE发生情况;分析宫内窘迫持续不同时间的新生儿SOD、丙二醛的变化及HIE发生情况。结果 (1)SOD水平检测:检测Ⅰ组为(12 896±247)U/gHb,检测Ⅱ组为(9846±268)U/gHb,对照组为(17 282±134)U/gHb。检测Ⅰ、Ⅱ组SOD水平分别与对照组比较,均显著降低,差异有统计学意义(P<0 01)。检测Ⅰ、Ⅱ组共发生HIE9例(HIE组),SOD水平为(7486±245)U/gHb,未发生HIE51例(非HIE组),SOD水平为(13 878±257)U/gHb,两组比较,差异有统计学意义(P<0 01)。检测Ⅰ、Ⅱ组宫内窘迫持续时间≤30min共19例,SOD水平为(17 411±324)U/gHb,持续时间31~120min共26例,SOD水平为(12 076±230)U/gHb,持续时间≥121min共15例,SOD水平为(9786±249)U/gHb。(2)丙二醛水平检测:检测Ⅰ组为(6 3±0 4)μmol/L,检测Ⅱ组为(8 6±1 5)μmol/L,对照组为(4 1±0 5)μmol/L,检测Ⅰ、Ⅱ组丙二醛水平显著高于对照组,两者比较,差异有统计学意义(P<0 01)。HIE组为

关 键 词:宫内窘迫 脐动脉血 丙二醛 临床意义 缺血缺氧性脑病(HIE) 超氧化物歧化酶(SOD) mol/L 新生儿HIE 持续时间 脂质过氧化水平 mol/L 胎儿窘迫 早期诊断指标 发生情况 水平检测 对照组 正常新生儿 moL/L 统计学 研究对象
修稿时间:2004-06-01

Clinical values of superoxide dismutase and malondialdehyde detection in cord blood of newborns with fetal distress
Qin Li-na,Feng Ai-hua,Yang Chuan-hua,Xing Hai-yan. Clinical values of superoxide dismutase and malondialdehyde detection in cord blood of newborns with fetal distress[J]. Chinese Journal of Obstetrics and Gynecology, 2005, 40(5): 312-314
Authors:Qin Li-na  Feng Ai-hua  Yang Chuan-hua  Xing Hai-yan
Affiliation:Department of Obstetrics and Gynecology, Fourth People's Hospital of Jinan, Jinan 250031, China.
Abstract:
OBJECTIVE: To investigate the relations between intrauterine asphyxia and peroxidation and newborn hypoxic-ischemic encephalopathy (HIE). METHODS: The levels of superoxide dismutase (SOD) and malondialdehyde (MDA) in cord blood of 60 newborns with intrauterine asphyxia during labor (which was divided into two groups, 39 cases with asphyxia in group I, and 21 cases with asphyxia in group II), and in 30 newborns without intrauterine asphyxia (control group) were determined. The levels of SOD and MDA in cord blood of newborns with HIE were compared with those in newborns without HIE. The incidence of HIE was estimated simultaneously. RESULTS: (1) The levels of SOD were (12,896 +/- 247) U/g Hb in group I, (9846 +/- 268) U/g Hb in group II, (17,282 +/- 134) U/g Hb in control group, significantly lower in the former two groups compared with control group, while the level of SOD in group I was higher than that in group II (P < 0.01). There were nine cases with HIE in groups I and II (HIE group), the level of SOD in these cases was (7486 +/- 245) U/g Hb. There were 51 cases with non-HIE (non-HIE group), the level of SOD in this group was (13,878 +/- 257) U/g Hb. There was significant difference in the level of SOD between HIE and non-HIE groups (P < 0.01). Nineteen cases were in < 30 min group, and the levels of SOD was (17 411 +/- 324) U/g Hb. Twenty-six cases were in 30 - 120 min group, and the levels of SOD was (12,076 +/- 230) U/g Hb. Fifteen cases were in > 121 min group, and the levels of SOD was (9786 +/- 249) U/g Hb. (2) The levels of MDA were (6.3 +/- 0.4) micromol/L in group I, (8.6 +/- 1.5) micromol/L in group II, and (4.1 +/- 0.5) micromol/L in control group, significantly higher in the former two groups compared with control group (P < 0.01). The levels of MDA were (10.6 +/- 0.6) micromol/L in HIE group and (5.1 +/- 0.8) micromol/L in non-HIE group, with significant difference between the two groups (P < 0.01). The levels of MDA were (4.2 +/- 0.3) micromol/L in or= 121 min group respectively. (3) None of HIE cases were in or= 121 min group. CONCLUSIONS: The results indicate that the incidence of intrauterine asphyxia is closely related to peroxidation, and intrauterine asphyxia may be an important factor in pathogenesis of HIE. The levels of SOD and MDA in cord blood may be regarded as one of the early predictive indexes for HIE.
Keywords:Fetal distress  Superoxide dismutase  Malonaldehyde  Hypoxia-ischemia   brain
本文献已被 CNKI 万方数据 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号