| P21~(WAF1/CIP1)、P16蛋白表达与人脑神经胶质瘤的相关分析 |
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| 引用本文： | 姜又红,隋承光,孟凡东,马萍,王晓华,戴晓淳. P21~(WAF1/CIP1)、P16蛋白表达与人脑神经胶质瘤的相关分析[J]. 癌变．畸变．突变, 2005, 0(5) |
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| 作者姓名： | 姜又红 隋承光 孟凡东 马萍 王晓华 戴晓淳 |
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| 作者单位： | 中国医科大学附属第一医院肿瘤研究所 辽宁沈阳110001(姜又红，隋承光，孟凡东，马萍，王晓华)，中国医科大学附属第一医院肿瘤研究所 辽宁沈阳110001(戴晓淳) |
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| 摘 要： | 背景与目的:探讨P21WAF1/CIP1、P16两种抑癌基因与人脑神经胶质瘤恶性程度的关系。材料与方法:采用SABC免疫组织化学方法对98例人脑胶质瘤组织及12例正常脑组织标本中P21WAF1/CIP1和P16的表达进行检测,并进行相关分析。结果:P21WAF1/CIP1和P16阳性表达率在人脑胶质瘤中分别为58.16%和42.86%,与正常脑组织中的表达情况差异有统计学意义;P21WAF1/CIP1蛋白和P16蛋白阳性表达率均随着胶质瘤的恶性程度的增高而降低;P21WAF1/CIP1蛋白和P16蛋白可协同表达。结论:P21WAF1/CIP1与P16蛋白的阳性表达率及协同表达率可在一定程度上反映胶质瘤细胞的恶性生物学行为,可以作为一项判断其恶性程度的有效指标。
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| 关 键 词： | 脑胶质瘤 P21蛋白 P16蛋白 免疫组织化学 |
Correlation Analysis Between Expression of P21 ~(WAF1/CIP1) ,P16 Proteins and Human Gliomas |
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| Abstract: | BACKROUND&ATM: To investigate the relationship between glioma malignancy grading and P21 WAF1/CIP1 ,P16gene expressing levels. MATERIAL AND METHODS: The expression levels of P21 WAF1/CIP1 and P16proteins were detected in98cases of brain glioma using SABC immunohistochemical staining.Eight normal brain tissues were used as control. RESULTS: The positive expression rates of P21 WAF1/CIP1 and P16protein in glioma were58.16%and42.86%respectively,anda significant difference was observed between gliomas and control.The expression intensity of P21 WAF1/CIP1 andP16 decreased with the gliomas grade increasing.Coexpression of P21 WAF1/CIP1 and P16was found in glioma and normal brain tissues. CONCLUSION: The positive expression rate and coexpression rate of P21 WAF1/CIP1 and P16protein may reflex the malignant grade of glioma in some extent,and they can be as a sensitive index for the gliomas grading. |
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| Keywords: | gliomas P21 WAF1/CIP1 protein P16protein immunohistochemistry |
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