羟基红花黄色素A对大鼠局灶性脑缺血-再灌注损伤的神经保护作用

用尼龙线栓塞法造成大脑中动脉（MCA）缺血模型的大鼠。2h后，尾静脉给予羟基红花黄色素A（1、2和4mg／kg）、尼莫地平（2mg／kg）或生理盐水。4h后取出尼龙线，得到局灶性缺血-再灌注模型。于缺血24h后观察的结果表明，相较于生理盐水组，中、高剂量羟基红花黄色素A可显著改善大鼠的神经学缺陷，减小脑梗死区比例，低剂量组仅可改善大鼠的神经学缺陷。各剂量组疗效均优于尼莫地平。病理组织学检查结果表明，各剂量组可略缓解梗死区神经细胞坏死情况。

Neuroprotective Effects of Hydroxysafflor Yellow A on Focal Cerebral Ischemia-Reperfusion Injury in Rats

Focal cerebral ischemia model was established by using nylon line occlusion of the middle cerebral arteryof rats. Hydroxysafflor yellow A(1, 2 and 4mg/kg), nimodipine(2mg/kg) and saline were administrated by caudal veininjection after ischemia for 2h. The focal cerebral ischemia-reperfusion model was obtained by taking out the nylon line after4h. The neurological deficit, the ratio of cerebral infarction area to total brain area and pathological histological changes ofcerebral infarction were investigated after ischemia for 24h. The results showed that compared with the saline group, themiddle and high dosage groups of hydroxysafflor yellow A could significantly improve the neurological deficit and decreasethe ratio of cerebral infarction, low dosage group could only improve the neurological deficit. The therapeutic effects of thethree groups were better than nimodipine group. The results of pathological histological examination showed thathydroxysafflor yellow A could modify the cellular necrosis status.