| 奈比洛尔对冠心病人内皮勃起功能及C反应蛋白的影响 |
| |
| 引用本文： | 宋巧凤,朱艳辉,陈荣花,刘春荣,赵楚敏,宋月霞.奈比洛尔对冠心病人内皮勃起功能及C反应蛋白的影响[J].西部医学,2010,22(1):43-45. |
| |
| 作者姓名： | 宋巧凤 朱艳辉 陈荣花 刘春荣 赵楚敏 宋月霞 |
| |
| 作者单位： | 唐山市人民医院心内科,河北,唐山,063000 |
| |
| 摘 要： | 目的观察第三代倍他受体阻滞剂奈比洛尔及第二代倍他受体阻滞剂美托洛尔对稳定型冠心病病人内皮功能、勃起功能及炎症指标的影响。方法本研究采用随机、对照的方法。80名35～67岁稳定型冠心病病人。符合入选条件者随机分为奈比洛尔和美托洛尔组。服药12周后比较两组病人血液中血管内皮功能变化及炎症的相关指标及勃起功能的变化。结果奈比洛尔组内皮功能相关指标一氧化氮（NO）水平、血流介导的血管扩张（FMD）明显高于服药前，而血管性血友病因子（vWF）水平、CRP（C反应蛋白）明显低于服药前。两组之间经过独立样本的t检验差异有显著性意义（P〈0．01），勃起功能明显好转。美托洛尔组内皮功能变化及炎症指标及勃起功能无显著性变化。结论第三代倍他受体阻滞剂奈比洛尔对稳定型冠心病病人具有改善血管内皮功能、勃起功能及炎症反应作用。
|
| 关 键 词： | 奈比洛尔 美托洛尔 一氧化氮 血管性血友病因子 血流介导的血管扩张 |
The impact of different beta-adrenoceptor blocker on endothelial function,erectile function and inflammation in stable coronary disease |
| |
| SONG Qiao-feng,ZHU Yan-hui,CHEN Rong-hua,et al.The impact of different beta-adrenoceptor blocker on endothelial function,erectile function and inflammation in stable coronary disease[J].Medical Journal of West China,2010,22(1):43-45. |
| |
| Authors: | SONG Qiao-feng ZHU Yan-hui CHEN Rong-hua |
| |
| Institution: | SONG Qiao-feng,ZHU Yan-hui,CHEN Rong-hua,et al(Department of Cardiology,The People Hospital of Tangshan,Tangshan 063000,Hebei,China) |
| |
| Abstract: | Objective The present study was performed to clarify the impact of endothelial function and inflammation index in stable coronary disease after using different beta-adrenoceptor blocker.Methods We compare von Willebrand factor(vWF,enzyme linked immunosorbent assay),flow-mediated dilatation(FMD,vascular ultrasound determination of endothelium dependent blood vessel dilation) and C-reactive protein(CRP,enzyme linked immunosorbent assay) between Metoprolol and nebivolol in 80 stable coronary disease.Patients a... |
| |
| Keywords: | Nebivolol NO vWF FMD Metoprolol |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
