纳洛酮在有机磷中毒治疗中的临床效果观察

目的探讨纳洛酮在临床治疗有机磷中毒中的应用价值。方法回顾性分析本院2008年3月～2013年3月64例急性有机磷农药中毒患者的临床资料，按治疗方法不同分为对照组（常规治疗）和实验组（常规治疗＋静滴纳洛酮），比较两组疗效。结果实验组治疗总有效率明显高于对照组（P〈0．01）；实验组患者治疗24、48、72h后胆碱酯酶活性与对照组比较，差异有统计学意义（P〈0.05）；实验组患者阿托品化时间、阿托品总用量、治愈时间以及住院时间均优于对照组（P〈0.01）。结论静脉滴注纳洛酮治疗急性有机磷中毒临床效果较好，患者恢复快，易于被多数患者所接受。值得临床推广。

Clinical observation of naloxone in rus intoxication the treatment of acute orgnophospho

Objective To investigate the application value of naloxone in treatment of acute orgnopbosphorus intoxication. Methods Clinical data of 64 eases of patients with orgnophosphorus intoxication who were treated in our hospital from March 2008 to March 2013 were reviewed, all patients were divided into control group（conventional treatment） and experimental group （conventional treatment＋intravenous naloxone）, then efficacy and recovery indicators of two groups were compared. Results The effective r~te of experimental group was higher than that of control groups （P〈 0.05）; after 24,48 and 72 h treatment, the ch0~inesterase reactivity of experimental group compared with the control group, the difference was significant （P〈0.05）. The total atropine time and atropine dosage, curing time and hospital stay of experimental group was better than that in control group respectively （P〈0.01）. Conclusion Intravenous naloxone has a significant effects on treating acute orgnophosphorus intoxication, which is worthy of clinical promotion.