| 络合钙在小鼠体内的药代动力学研究 |
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| 引用本文： | 张丽萍,赵红杰,王岑,许国,杨璇,孙建和.络合钙在小鼠体内的药代动力学研究[J].中国生化药物杂志,2000,21(2):71-72. |
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| 作者姓名： | 张丽萍 赵红杰 王岑 许国 杨璇 孙建和 |
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| 作者单位： | 550002,贵阳市食品生物工程研究所 |
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| 基金项目： | 贵州省科学技术基金资助项目 |
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| 摘 要： | 目的：测定络含钙在小鼠体内的血药浓度，对其进行药代动力学研究。方法：口服给予高、低两个剂量的络合钙，于给药后不同时间采用原子吸收法测定血钙浓度，并与维丁钙片进行比较，对所得参数用计算机进行房室模型模拟。结果：高、低络含钙组以及维丁钙组小鼠的血钙浓度明显升高，高剂量组的血钙浓度明显高于维丁钙组（P≤0．01）。所得的动力学参数经计算机模拟表明络合钙在体内的药代动力学符合一室模型。结论：络合钙口服可明显提高小鼠的血钙水平。
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| 关 键 词： | 络合钙 药代动力学 小鼠 |
| 修稿时间： | 1999-08-02 |
Pharmacokinetic Study of Complex Calcium in Mice |
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| Zhang Liping,Zhao Hongjie,Wang Cen,Xu Guo,Yang Xuan,Sun Jianhe.Pharmacokinetic Study of Complex Calcium in Mice[J].Chinese Journal of Biochemical Pharmaceutics,2000,21(2):71-72. |
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| Authors: | Zhang Liping Zhao Hongjie Wang Cen Xu Guo Yang Xuan Sun Jianhe |
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| Institution: | Zhang Liping
,Zhao Hongjie
,Wang Cen
,Xu Guo
,Yang Xuan
,Sun Jianhe
(Guiyang Institute for Food and Biological Engineering Guiyang 550002) |
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| Abstract: | Purpose: To study pharmacokinetics of complex calcium in mice after oral administration. Methods: Mice were given high or low dose of complex calcium and the plasma calcium concentration was assayed by atomic absorption spectrophometry at different duration after administration,and the results were compared with another calcium preparation as control.The pharmacokinetics parameters obtained were computerized to evaluate the model of complex caicium. Results: Higher and lower dose complex calcium could elevate calcium plasma level as well as control. The plasma calcium concentration of mice in the group of higher dose was higher than that of control (P ≤0.01 ). Conclusion:Complex calcium could elevate plasma calcium level of mice after oral adminstration, and its pharmacokinetics was accordant with one compartment model. |
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| Keywords: | Complex calcium Pharmacokinetics Mice |
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