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| 应用褶合曲线分析法同时测定菌克星注射液2种组分含量 | |
| 引用本文： | 刘元瑞 郭吉蓉. 应用褶合曲线分析法同时测定菌克星注射液2种组分含量[J]. 武警医学, 1999, 10(7): 375-377 |
| 作者姓名： | 刘元瑞 郭吉蓉 |
| 作者单位： | 武警部队药品检验所，武警四川总队医院 |
| 摘 要： | 目的建立菌克星注射液的含量测定方法。方法采用褶合曲线分析法不经分离直接测定菌克星注射液中替硝唑和环丙沙星两组分的含量，选定替硝唑测定波长为３０７０ｎｍ（Ｎ＝１３，Ｈ＝１）；乳酸环丙沙星测定波长为２５９４ｎｍ（Ｎ＝９，Ｈ＝２）。结果平均回收率分别为９９６０％和９９７７％，ＲＳＤ分别为０３２％和０７４％。结论该方法快速、简便，结果准确，可作为菌克星注射液的质量标准。 |
| 关 键 词： | 褶合曲线分析法 替硝唑 环丙沙星 |
Application of convolution curve to simultaneous determination of tinidazole and ciprofloxacin in compound injection of the two comfaonents |
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| Liu Yuanrui,Wang Jie,Yu Ling,Guo Jirong,Zhou Yanping and Jiang Junde.Institute for Drug Control,Chinese People's Armed Police Forces,Beijing ,China. Application of convolution curve to simultaneous determination of tinidazole and ciprofloxacin in compound injection of the two comfaonents[J]. Medical Journal of the Chinese People's Armed Police Forces, 1999, 10(7): 375-377 | |
| Authors: | Liu Yuanrui Wang Jie Yu Ling Guo Jirong Zhou Yanping Jiang Junde.Institute for Drug Control Chinese People's Armed Police Forces Beijing China |
| Affiliation: | Liu Yuanrui,Wang Jie,Yu Ling,Guo Jirong,Zhou Yanping and Jiang Junde.Institute for Drug Control,Chinese People's Armed Police Forces,Beijing 102613,China |
| Abstract: | Objective To build the assay method of tiniadzo and ciprofloxacin components. Methods Convolution curve method was used to determine tinidazole and ciprofloxacin in the compound injection without prior separation.The determined wavelength of tinidazole and ciprofloxacin were 307.0 nm(N=13,H=1) and 259.4 nm(N=9,H=2),respectively. Results The reasult showed that the corresponding average recovery rates were 99.60% and 99.77%,and RSD were 0.32% and 0.74%. Conclusion This method is rapid,simple and precise.So it can be used for quality control of the compound injection of tinidazole and ciprofloxacin. |
| Keywords: | Convolution curveTinidazoleCiprofloxacin |
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