| 霉酚酸酯治疗难治性肾病综合征的临床分析研究 |
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| 引用本文： | 常巨平 张军 余学清. 霉酚酸酯治疗难治性肾病综合征的临床分析研究[J]. 医学研究杂志, 2001, 30(3): 15-18 |
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| 作者姓名： | 常巨平 张军 余学清 |
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| 作者单位： | 1. 深圳市南山人民医院,518052
2. 中山医科大学附属第一医院肾内科 |
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| 摘 要： | 目的通过霉酚酸酯(MMF)在难治性肾病综合征的临床疗效观察,探讨MMF治疗难治性肾综的适应症.方法经肾活检及临床诊断为难治性肾综患者21例,观察MMF治疗后第4周、8周、12周及16周各项临床指标变化,对其疗效进行评价.结果MMF能有效降低难治性肾综患者24小时尿蛋白总量(P＜0.01),血清白蛋白水平上升(P＜0.01).总有效率为85.7%.MCD和MesPGN对MMF反应良好(有效率100%),FSGS和MN疗效较差,3例(3/5)无效.所有病例对MMF有良好耐受性.结论MMF能有效缓解难治性肾综,疗效良好.
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| 关 键 词： | 霉酚酸酯 难治性肾病综合征 |
| 修稿时间： | 2000-10-25 |
Effect of mycophenolate Mofetil (MMF) in Treatment Refractory Nephropathy Syndrome |
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| Chang Juping,Zhang Jun,Yu Xueqing. Nephrology department,Nanshan hospital,Shenzhen,Guangdong. Effect of mycophenolate Mofetil (MMF) in Treatment Refractory Nephropathy Syndrome[J]. Journal of Medical Research, 2001, 30(3): 15-18 |
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| Authors: | Chang Juping Zhang Jun Yu Xueqing. Nephrology department Nanshan hospital Shenzhen Guangdong |
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| Affiliation: | Chang Juping,Zhang Jun,Yu Xueqing. Nephrology department,Nanshan hospital,Shenzhen,Guangdong 518052 |
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| Abstract: | Objective To investigate the effect of mycophenolate mofetil (MMF) in treatment refractory nephropathy syndrome.Methods The 21 refractory nephropathy syndrome patients were diagnosed by renal biopsy, and received MMF therapy.The clinical data was observed in 4th week, 8th week, 12 th week and 16th week.Results The proteinuria were decreased significandy after received MMF therapy in refractory nephropathy syndrome. Serum albumin were increased significandy ( P < 0.01) .Total efficiency was 85.7% .There were a significance effects in MCD and MesPGN, but not in FSGS and MN. No serious side effects was observed. Conclusion MMF is a efficient medicine to treat refractory nephropathy syndrome. |
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| Keywords: | Mycophenolate mofetil Refractory nephropathy syndrome |
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