症状性颅内动脉狭窄的治疗现状

颅内动脉狭窄是缺血性卒中的重要原因之一。过去20年内，关于药物、血管内介入治疗颅内动脉狭窄的报道有很多，其中药物试验中WASID证实阿司匹林优于华法林，但颅内动脉狭窄度70％～99％在药物系统治疗后仍有较高的卒中风险。初期的研究提示血管成形术和支架置入术可降低此类患者的卒中风险，但缺乏前瞻、随机对照研究。因此，血管内介入术治疗症状性颅内动脉狭窄的合理性尚在研究探索中。

Rationality of endovascular intervention for symptomatic intracranial stenosis

Intracranial stenosis is one of the important causes of ischemic stroke.Over the past 2 decades,a number of reports and prospective multicenter trials have been published regarding medication,intracranial angioplasty and stenting for the treatment of the disease.The warfarin-aspirin for symptomatic intracranial stenosis(WASID) trial showed that aspirin was more effective and safer than warfarin for preventing stroke or vascular death in these patients,and that patients with 70%-99% intracranial stenosis wer...