Effect of ultralow doses of thyroliberin on microviscosity of lipid components of biological membranes |
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| Authors: | N G Bogdanova T V Lelekova N P Pal'mina |
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| Institution: | (1) N. M. Emanuel' Institute of Biochemical Physics, Russian Academy of Sciences, Moscow;(2) Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia |
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| Abstract: | Effects of the regulatory peptide thyroliberin on microviscosity of lipid components of endoplasmic reticulum biological membranes
in mouse hepatocytes were studied by electron paramagnetic resonance. Thyroliberin in a concentration of 10−3–10−18 M decreased microviscosity of surface layers of membrane lipids. This decrease was the most pronounced (30%) under effects
of 10−10 and 10−16 M thyroliberin. Physiological effects of thyroliberin corresponded to its influence on the membrane structure.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 129, No. 1, pp. 38–40, January, 2000 |
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| Keywords: | thyroliberin biological membrane microviscosity |
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