| 神经节苷脂对急性低氧大鼠脑皮层神经元的保护作用研究 |
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| 引用本文： | 谢印芝,张波,杨曦明,尹昭云,白景文,杨海贤. 神经节苷脂对急性低氧大鼠脑皮层神经元的保护作用研究[J]. 航天医学与医学工程, 2000, 13(3): 191-195 |
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| 作者姓名： | 谢印芝 张波 杨曦明 尹昭云 白景文 杨海贤 |
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| 作者单位： | 军事医学科学院卫生学环境医学研究所,天津,300050;天津医科大学电镜测试中心,天津,300701 |
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| 摘 要： | 目的 观察外源性神经节苷脂对急性减压低氧大鼠脑神经元的保护作用,为临床应用提供依据。方法 １５只Ｗｉｓｔａｒ大鼠随机分为：低氧组Ａ、低氧组Ｂ与常氧组。低氧组Ａ置于海拔７０００ｍ,持续５ｈ,低氧组Ｂ在低氧３ｄ前腹腔注射神经节苷脂（１００ｍｇ／ｋｇ／ｄ）,其余与低氧组Ａ相同。电镜观察各组脑皮层神经元的超微结构改变。结果 低氧组Ｂ动物的脑神经元胞体、细胞骨架和突触结构损伤的程度明显轻于低氧组Ａ。结论 神
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| 关 键 词： | 急性高空缺氧 神经节苷脂类 超微结构 神经元 大鼠 |
| 修稿时间： | 1999-09-16 |
Protective Effects of Gangliosides on Cerebral Neuronal Damage of Rat during Acute Hypoxia |
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| XIE Yin-zhi,ZHANG Bo,YANG Xi-ming,YIN Zhao-yun,BAI Jing-wen,YANG Hai-xian. Protective Effects of Gangliosides on Cerebral Neuronal Damage of Rat during Acute Hypoxia[J]. Space Medicine & Medical Engineering, 2000, 13(3): 191-195 |
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| Authors: | XIE Yin-zhi ZHANG Bo YANG Xi-ming YIN Zhao-yun BAI Jing-wen YANG Hai-xian |
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| Affiliation: | Institute of Hygiene and Environmental Medicine Academy of Military Medical Sciences, Tianjin, China. |
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| Abstract: | Objective: To observe the preventive and therapeutic effects of gangliosides on acute altitude hypoxic brain damage. Method: Fifteen Wistar rats, weighed 180-220 g, were randomly divided into 3 groups, hypoxia group A, hypoxia group B and normoxia group. The rats in hypoxia group A were exposed to a simulated altitude of 7000 m for 5 hours and the rats in hypoxia group B were exposed to hypoxia after intraperitoneal administration of mixed gangliosides (100 mg/kg/d) for 3 days. Result: Gangliosides could ameliorate the severity of damage in neuronal bodies, cellular skeletons and synapses, especially in synapses. Conclusion: It is suggested that gangliosides are effective in preventing and treating hypoxic brain damages by decreasing the accumulation of intracellular Ca2+, and stabilizing CaM and CaM PKII activity during acute hypoxia. |
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| Keywords: | acute altitude
hypoxia gangliosides ultrastructure neurons rats |
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