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| 弥散性血管内凝血模型的改进 | |
| 引用本文： | 王艳春,吕莉. 弥散性血管内凝血模型的改进[J]. 吉林医药学院学报, 2005, 26(2): 67-70 |
| 作者姓名： | 王艳春 吕莉 |
| 作者单位： | 1. 吉林医药学院药理教研室,吉林,吉林,132013 2. 大连医科大学药理教研室,辽宁,大连116023 |
| 摘 要： | 目的改进弥散性血管内凝血(DIC)的模型。方法采用凝血酶(100U/kg×1h)和氨基己酸(50mg/kg×1h)静脉滴注造成家兔急性DIC模型,以凝血酶原时间(PT)、血小板计数(PLT)、纤维蛋白原(FIB)含量和血浆鱼精蛋白副凝固(3P)试验以及肺、肾微血栓形成为观察指标。结果模型组PT进行性延长、PLT进行性下降、FIB进行性降低、3P试验由阴性转为阳性,且肺、肾病理切片有微血栓形成。结论采用凝血酶和氨基己酸静脉滴注能够成功地诱发DIC。 |
| 关 键 词： | 凝血酶 弥散性血管内凝血 模型 |
| 文章编号： | 1009-8488(2005)02-0067-03 |
| 修稿时间： | 2005-04-05 |
Improvement the model of disseminated intravascular coagulation (DIC) |
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| WANG Yan-chun,Lü Li. Improvement the model of disseminated intravascular coagulation (DIC)[J]. Journal of Jilin Medical College, 2005, 26(2): 67-70 | |
| Authors: | WANG Yan-chun Lü Li |
| Abstract: | Objective To improve the model of disseminated intravascular coagulation (DIC).Methods DIC was induced by constant iv infusion of thrombin plus PAMBA in rabbits.Platelet count (PLT), PT and fibrinogen (FIB) content plasmaprotamine paracoagulation (3P) test and pathlogical examination of microthrombosis of lungs and kidneys were served as diagnostic indexes of DIC.Results PT in model group was prolonged, PLT and FIB were decreased, 3P test was changed from positive to negative and microthrombosis of lungs and kidneys were formed.Conclusion Iv infusion of thrombin plus PAMBA constant in rabbits can succeed in inducing the DIC. |
| Keywords: | thrombin DIC model |
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