轻型脑损伤患者血清S-100蛋白检测的临床意义

目的探讨S-100蛋白检测在轻型脑损伤患者中的临床应用价值。方法选择80例格拉斯哥昏迷（GCS）评分在13—15分间的头部外伤病人，进行头部CT扫描和使用电化学发光法检测病人血清S-100蛋白水平，并进行统计学分析。结果34例病人血清S-100蛋白呈阳性，占42％，其中4例病人CT呈阳性占5％；46例病人血清S-100蛋白呈阴性占58％，CT检查均呈阴性。以cT阳性作为脑损伤的判断标准相比较，S-100蛋白的灵敏度为100％，阴性预测值为100％。结论S-100蛋白检测能更好的预测头部外伤病人的颅内出血情况。

Clinical significance of detection of S-100 protein in patients with light trauma in the head.

Objective To explore the clinical significance of detection of S-100 protein in patients with light trauma in the head. Methods Eighty patients with Glasgow Coma Scale scores of 13-15 were selected. Serum levels of S-100 protein were measured by electrochemiluminescence immunoassay and CT scanning of the brain were performed in all patients. The results were statistically analyzed. Results S-100 protein was detected in 34 patients accounted for 42%, and CT scan demonstrated intracranial positive for S-100 protein in 4 patients （5%）. S-100 protein was not detected in 46 patients accounted for 58% so did the CT scan. Taking the positive results of CT scan as criteria for diagnosis of brain trauma, the sensitivity and negative predicative value of S-100 level were all 100%. Conclusions Serum levels of S-100 protein might disclose the intracranial bleeding in patients with trauma in the head.