羚羊清肺颗粒中冰片的含量测定

目的：制订羚羊清肺颗粒中冰片的含量测定方法。方法采用《中国药典》2010年版一部附录ⅥE规定的气相色谱测定方法：色谱柱：HP20M（30 m×0.32 mm×1.0μm）（PEG20M）；柱温：140℃；气化温度：280℃；检测器温度：300℃；载气：氮气（色谱纯）；流速：35.5 mL/min；分流比：40：1；进样量：1μL。结果羚羊清肺颗粒中冰片称样量在1.85~11.13 mg范围内呈良好的线性关系，平均回收率在97.71%~101.24%之间，RSD为1.35%（n越6），符合《中国药典》2010年版一部规定，其他方法学考查均符合《中国药典》2010年版一部规定。结论本研究所采用的气相色谱法操作快速、简便、易行，精密度、重复性、稳定性好，可用于羚羊清肺颗粒中冰片的含量测定。

Content determination of borneol in Lingyang Qingfei Granules

Objective To establish a method for determination of the borneol content of Lingyang Qingfei Granules. Methods Gas chromatography in Appendix ⅥE of Chinese Pharmacopeia （2010 edition, 1 volume） determination was used as follow： chromatographic column： HP20M （30 mí0.32 mmí1.0 μm） （PEG20M）; column temperature： 140℃;gasification temperature： 280℃; detector temperature： 300℃; carrier gas： Nitrogen （chromatographic purity）; flow rate：35.5 mL/min, the split ratio： 40：1; sample size： 1 μL. Results Borneol of Lingyang Qingfei Granules in the sample weight in the range of 1.85-11.13 mg showed a good linear relationship, the average rate of recovery was 97.71%-101.24%, RSD was 1.35% （n=6）, in accordance with the relevant provisions, other methods of study were in confor-mity with the relevant provisions. Conclusion This method of GC is rapid, simple, and convenient to operate, its preci-sion, repeatability and stability are all good, it can be used for the content determination of borneol of Lingyang Qingfei Granules.