慢性阻塞性肺疾病急性加重期患者近期预后的多因素分析

目的探讨影响慢性阻塞性肺病急性加重期(AECOPD)患者近期预后的主要相关因素。方法对190例住院治疗的慢性阻塞性肺病急性加重期患者,共五大类32项因素进行回顾性单因素分析,对单因素分析中P<0.2的因素进行Logistic多元逐步回归分析,寻找影响AECOPD患者近期预后的主要相关因素。结果多因素分析结果显示:是否使用呼吸兴奋剂、是否使用抗氧化剂、抗生素选择、淋巴细胞计数、白细胞计数、是否合并右心功能不全、血红蛋白、血肌酐值等因素是影响近期预后的主要因素。结论影响AECOPD近期预后的主要因素较多,其中,白细胞计数和淋巴细胞计数是影响预后的独立因素。

Multiple-factor analysis of acute exacerbation of chronic obstructive pulmonary diseases for the short-term prognosis

Objective To guide the treatment of acute exacerbation of chronic obstructive pulmonary diseases （AECOPD） through studing the principally related factors of AECOPD. Methods 190 AECOPD patients were investigated. First ,we studied the thirty-two possible factors with single-factor analysis ,then perform multiple-factor analysis with Logistic regression among the factors which P value was below 0. 2 in single-factor analysis, and analyzed the principally related factors with two-factor correlation. Results According to Multiple-factor analysis with Logistic regression analysis, there were eight factors that showed significance, which were the usage of respiratory excitant, LBC, usage of antioxidant, heart failure, blood Cr, selection of antibiotics, blood WBC and Hb, respectively. Condusion Many risk factors can influence the prognosis of patients with AECOPD,the inpendent risk factors are the blood WBC and LBC account.