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| 喉鳞癌中内皮细胞特异性分子1的表达及临床意义 | |
| 引用本文： | 曹峰,徐洁洁,乔明哲,陈曦,陆美萍,汪渊. 喉鳞癌中内皮细胞特异性分子1的表达及临床意义[J]. 江苏医药, 2008, 34(5): 454-456 |
| 作者姓名： | 曹峰 徐洁洁 乔明哲 陈曦 陆美萍 汪渊 |
| 作者单位： | 南京医科大学第一附属医院耳鼻咽喉科,210029;安徽医科大学分子生物学实验室,省部共建教育部和安徽省重要遗传病基因资源利用重点实验室 |
| 摘 要： | 目的 探讨喉鳞癌组织中内皮细胞特异性分子1(ESM-1)表达及其临床意义.方法 采用免疫组化SP法对50例喉鳞癌组织和40例癌旁对照组织ESM-1蛋白表达情况进行检测.同时采用Western blot检测20例喉鳞癌及15例癌旁新鲜标本中ESM-1蛋白的表达.结果 两种方法检测结果均显示喉鳞癌组织中ESM-1表达显著高于癌旁对照组织(P＜0.01).Ⅲ～Ⅳ期喉鳞癌组织ESM-1的表达明显高于Ⅰ～Ⅱ期的表达;伴有颈淋巴结转移的喉鳞癌组织的ESM-1表达明显高于无淋巴结转移组.结论 ESM-1在喉鳞癌组织中高表达,并且其表达程度与喉鳞癌的分期及是否存在淋巴结转移有关,提示ESM-1的表达与喉鳞癌的发生、发展可能相关. |
| 关 键 词： | 喉癌 鳞状细胞癌 内皮细胞特异性分子1 |
| 文章编号： | 0253-3685(2008)05-0454-03 |
| 修稿时间： | 2008-01-23 |
Expression and clinical significance of endocellular specific molecule-1 in laryngeal carcinoma |
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| CAO Feng,XU Jiejie,QIAO Mingzhe,et al.. Expression and clinical significance of endocellular specific molecule-1 in laryngeal carcinoma[J]. Jiangsu Medical Journal, 2008, 34(5): 454-456 | |
| Authors: | CAO Feng XU Jiejie QIAO Mingzhe et al. |
| Affiliation: | CAO Feng,XU Jiejie,QIAO Mingzhe,et al.Department of Otorhinolaryngology,First Affiliated Hospital,Nanjing Medical University,Nanjing 210029,CHINA |
| Abstract: | Objective To investigate the expression and clinical significance of endocellular specific molecule-1(ESM-1) in laryngeal carcinoma. Methods The expression of ESM-1 protein in 50 laryngeal carcinoma tissues and 40 tumor-adjacent tissues was measured by immunohistochemistry,and Western blot was used to detect the expression of ESM-1 in 20 fresh laryngeal carcinoma tissues and 15 tumor-adjacent tissues. Results The qualitative expression of ESM-1 in laryngeal carcinoma tissues was significantly higher than th... |
| Keywords: | Laryngeal carcinoma Squamous cell carcinoma Endocellular specific molecule-1 |
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