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'Fat mass and obesity associated' gene ( |
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| Authors: | Timo D Müller Anke Hinney André Scherag Thuy T Nguyen Felix Schreiner Helmut Schäfer Johannes Hebebrand Christian L Roth Thomas Reinehr |
| Affiliation: | (1) Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg-Essen, Essen, Germany;(2) Biometry and Epidemiology, Institute of Medical Informatics, University of Duisburg-Essen, Essen, Germany;(3) Institute of Medical Biometry and Epidemiology, Philipps-University, Marburg, Germany;(4) Children's Hospital Medical Center, University of Bonn, Germany;(5) Children's Hospital & Regional Medical Center, University of Washington, Seattle, USA;(6) Vestische Kinder- und Jugendklinik, University of Witten/Herdecke, Datteln, Germany |
| Abstract: | BackgroundWe have previously identified strong association of six single nucleotide polymorphisms (SNPs) in FTO (fat mass and obesity associated gene) to early onset extreme obesity within the first genome wide association study (GWA) for this phenotype. The aim of this study was to investigate whether the obesity risk allele of one of these SNPs (rs9939609) is associated with weight loss in a lifestyle intervention program. Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism. |
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