孤独症谱系障碍儿童营养情况与血清矿物质含量分析

目的 评估孤独症谱系障碍(ASD)儿童营养状态和血清11种矿物质含量.方法 选取2019年1～12月在沈阳市儿童医院诊断ASD患儿126例为ASD组和同期于儿童保健科体检儿童200例为对照组.采用电感耦合等离子体质谱法检测血清钙、铁、锌、硒、镁、铜、锰、锂、钴、镍、汞11种矿物质含量.观察两组儿童异常营养状态情况.结果...

Research in the nutritional status and serum mineral content of children with autism spectrum disorder

Objective To evaluate the nutritional status of children with autism spectrum disorder(ASD)and the content of 11 minerals in serum.Methods 126 children who were diagnosed with ASD in Shenyang Children's Hospital from January to December,2019 were selected as the ASD group,and another 200 children who were examined in the Child Healthcare Department of Shenyang Children's Hospital during the same period were selected as the control group.The contents of calcium,iron,zinc,selenium,magnesium,copper,manganese,lithium,cobalt,nickel and mercury in serum were determined by Inductively coupled plasma mass spectrometry(ICP-MS).Results The incidence of low body weight in ASD group was(8.7%,11/126),higher than that in control group(2.5%,5/200),and the difference was statistically significant(P<0.05).Serum zinc/copper,selenium and lithium in ASD group were lower than those in control group,while copper,manganese and mercury were higher than the control group(P<0.01).Conclusion ASD children have deficiency of trace elements lithium and selenium,and excess of heavy metals copper and mercury.Clinicians should pay attention to the balance of minerals in ASD children,and provide dietary intervention and nutrition guidance to ASD children.