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Patient-Specific Sarcoma Organoids for Personalized Translational Research: Unification of the Operating Room with Rare Cancer Research and Clinical Implications |
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| Authors: | Forsythe Steven D. Sivakumar Hemamylammal Erali Richard A. Wajih Nadeem Li Wencheng Shen Perry Levine Edward A. Miller Katherine E. Skardal Aleksander Votanopoulos Konstantinos I. |
| Affiliation: | 1.Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA ;2.Department of Cancer Biology, Wake Forest School of Medicine, Winston-Salem, NC, USA ;3.Wake Forest Organoid Research Center (WFORCE), Winston-Salem, NC, USA ;4.Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA ;5.Department of Surgery, Division of Surgical Oncology, Wake Forest Baptist Health, Wake Forest University, Winston-Salem, NC, USA ;6.Comprehensive Cancer Center, Wake Forest School of Medicine, Winston-Salem, NC, USA ;7.Department of Pathology, Wake Forest School of Medicine, Winston-Salem, NC, USA ;8.The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children’s Hospital, Columbus, OH, USA ;9.Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA ;10.The Ohio State University and Arthur G. James Comprehensive Cancer Center, Columbus, OH, USA ; |
| Abstract: | Annals of Surgical Oncology - Sarcoma clinical outcomes have been stagnant for decades due to heterogeneity of primaries, lack of comprehensive preclinical models, and rarity of disease. We... |
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