某退役铀矿山周围居民淋巴细胞微核率分析

目的 调查某退役铀矿山周围居民外周血淋巴细胞微核情况，初步探讨环境因素对微核的影响，为综合治理退役铀矿周围环境提供科学依据。方法 采集100名退役铀矿山周围居民外周静脉血，用常规淋巴细胞微核培养法，检查淋巴细胞微核，进行统计分析。结果 在100名居民中，微核检出率为88.0%，细胞微核率（9.46±6.62）‰、微核细胞率为（8.77±5.92）‰；按性别和年龄分别分组分析得出，细胞微核率和微核细胞率整体随着年龄的增加而增加，但男性和女性增加的速度和幅度在各年龄段稍有不同，男性各组间无明显差异（P>0.05），女性微核细胞率各组间无明显差异（P>0.05），细胞微核率各组间差异具有统计学意义（P<0.05）。结论 该退役铀矿山周围居民外周血淋巴细胞微核检出率、淋巴细胞微核率和微核细胞率远超过国内外报道的本底范围，应对退役铀矿周围环境采取更具针对性的综合治理措施，以确保退役铀矿山周围居民的健康。

Analysis of the micronucleus rate of peripheral blood lymphocytes of healthy residents around a retired uranium mine

Objective To investigate the micronuclei frequencies in peripheral blood lymphocytes of residents around a retired uranium mine. And the influences of environmental factors on micronuclei were preliminarily discussed, which provide scientific basis for the comprehensive treatment of the surrounding environment of the retired uranium mine.Methods Peripheral venous blood was collected from 100 healthy residents around decommissioned uranium mines, the conventional culture method for lymphocytes and X² test were used to analyze the micronucleus rates statistically.Results Among the 100 healthy residents, the micronucleus detection rate was 88.0%, the micronucleus rate (MNR) was (9.46±6.62) ‰ and the micronucleus cell rate (MN cell rate) was (8.77±5.92) ‰. The MNR and MN cell rate increased with the increase of ages, but the rate and magnitude of increase were slightly different in men and women at different ages. There was no significant difference between the male groups(P>0.05) and no significant difference of MNR between the female groups(P>0.05), but the differences of MN cell were statistically significant in groups of female(P<0.05).Conclusion The detection rates of micronucleus and micronucleus cells in peripheral blood of healthy residents around the retired uranium mine are far higher than the background range reported at home and abroad. Therefore more targeted comprehensive management measures should be taken to ensure the health of the residents around the decommissioned uranium mines.