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A Translational Randomized Trial of Perioperative Arginine Immunonutrition on Natural Killer Cell Function in Colorectal Cancer Surgery Patients |
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| Authors: | Angka Leonard Martel Andre B. Ng Juliana Pecarskie Amanda Sadiq Manahil Jeong Ahwon Scaffidi Marlena Tanese de Souza Christiano Kennedy Michael A. Tadros Shaheer Auer Rebecca C. |
| Affiliation: | 1.Cancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada ;2.Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada ;3.Department of Surgery, University of Ottawa, Ottawa, Ontario, Canada ;4.Division of General Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada ;5.Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada ;6.Centre for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON, Canada ; |
| Abstract: | Annals of Surgical Oncology - Surgery results in severe impairment of natural killer (NK) cell cytotoxicity (NKC) and activity (NKA, cytokine secretion), and a dramatic drop in arginine levels.... |
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