| 小鼠体内斑蝥对白细胞介素2和细胞介素1产生的影响 |
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| 引用本文： | 张俊平 齐荔红. 小鼠体内斑蝥对白细胞介素2和细胞介素1产生的影响[J]. 中国药理学报, 1992, 13(3): 263-264 |
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| 作者姓名： | 张俊平 齐荔红 |
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| 摘 要： |
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| 关 键 词： | 斑蝥素 白细胞介素1 白细胞介素2 |
Effects of cantharidin on interleukin-2 and interleukin-1 production in mice in vivo. |
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| J P Zhang,D H Qian,L H Qi. Effects of cantharidin on interleukin-2 and interleukin-1 production in mice in vivo.[J]. Acta Pharmacologica Sinica, 1992, 13(3): 263-264 |
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| Authors: | J P Zhang D H Qian L H Qi |
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| Affiliation: | Research Laboratory of Natural and Synthetic Drugs, School of Pharmacy, Second Military Medical University, Shanghai, China. |
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| Abstract: | After cantharidin (0.75, 1.5 mg.kg-1) was given ip 3 times every other day in mice, Con A-induced spleen lymphocyte proliferation, as measured by [3H]TdR incorporation assay, was enhanced from 7,978 +/- 1,780 to 36,631 +/- 8,467 and 29,997 +/- 3,788 dpm in both doses. Interleukin-2 and interleukin-1 production were also increased from 11 +/- 4 to 52 +/- 18, 23 +/- 6 U.ml-1 and from 7,628 +/- 1,477 to 14,532 +/- 2,272, 11,515 +/- 2,862 dpm, respectively. These results suggest that cantharidin potentiates immune response through the release of interleukin-2 and interleukin-1. |
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