| 大鼠结扎左冠脉后全心性去甲肾上腺素和腺苷三磷酸... |
| |
| 引用本文： | 荣沛 戴德哉. 大鼠结扎左冠脉后全心性去甲肾上腺素和腺苷三磷酸...[J]. 中国药理学报, 1992, 13(4): 333-337 |
| |
| 作者姓名： | 荣沛 戴德哉 |
| |
| 摘 要： | ![]()
|
| 关 键 词： | 心肌梗死 普萘洛尔 肾上腺素 |
Global depletion of myocardial norepinephrine and ATP after left coronary artery occlusion in rats. |
| |
| P Rong,D Z Dai,J E Zhang. Global depletion of myocardial norepinephrine and ATP after left coronary artery occlusion in rats.[J]. Acta Pharmacologica Sinica, 1992, 13(4): 333-337 |
| |
| Authors: | P Rong D Z Dai J E Zhang |
| |
| Affiliation: | Research Division of Pharmacology, China Pharmaceutical University, Nanjing. |
| |
| Abstract: | ![]()
After ligation of the left coronary artery in rats, myocardial norepinephrine (NE) and ATP depletions in both infarcted (IZ) and non-infarcted zone (NIZ) were studied. In IZ, the depletions of NE and ATP were biphasic and the depleting rate constants were found to be K1 = 0.71 h-1 and K2 = 0.015 h-1 for NE, and K1' = 0.52 h-1 and K2' = 0.016 h-1 for ATP. In NIZ, the depletion of NE was monophasic, slowly progressive, and quite durable with rate constant K3 = 0.018 h-1. The depletion of ATP was transient. Propranolol (Pro) and verapamil (Ver) were beneficial but only partly effective against NE and ATP depletions. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
|
