| 可乐定对动物烫伤后溶血的抑制作用 |
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| 引用本文： | 王培 陶静仪. 可乐定对动物烫伤后溶血的抑制作用[J]. 中国药理学报, 1992, 13(1): 45-47 |
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| 作者姓名： | 王培 陶静仪 |
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| 摘 要： | ![]()
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| 关 键 词： | 抑制作用 运行 烧伤 可乐定 溶血 |
Inhibitory effect of clonidine on hemolysis after thermal injury in animals] |
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| P Wang,J Y Tao,S Y Xu. Inhibitory effect of clonidine on hemolysis after thermal injury in animals][J]. Acta Pharmacologica Sinica, 1992, 13(1): 45-47 |
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| Authors: | P Wang J Y Tao S Y Xu |
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| Affiliation: | Department of Pharmacology, Fourth Military Medical University, Xi-an, China. |
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| Abstract: | ![]()
Clonidine (1 mg.kg-1, ip) inhibited hemolysis in mice and rats after burn. The effects were abolished by pretreatment with yohimbine (5 mg.kg-1, ip) but not by prazosin (10 mg.kg-1, ip). The increased osmotic fragility of erythrocytes and the elevation of plasma NE level in burned animals were markedly lowered by clonidine which also raised the glutathione level of whole blood and enhanced the activity of glutathione peroxidase. These results indicated that the action of clonidine on hemolysis was carried out by means of depression of adrenergic alpha 2 receptors and reduction of free radicals. |
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