| 酮替芬对人血中性粒细胞呼吸爆发和细胞内游离... |
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| 引用本文： | 辛小华 卞如濂. 酮替芬对人血中性粒细胞呼吸爆发和细胞内游离...[J]. 中国药理学报, 1992, 13(4): 367-370 |
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| 作者姓名： | 辛小华 卞如濂 |
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| 摘 要： | ![]()
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| 关 键 词： | 酮替芬 中性白细胞 鲁米诺 钙 |
Effects of ketotifen on human neutrophil respiratory burst and intracellular free calcium] |
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| X H Xin,R L Bian. Effects of ketotifen on human neutrophil respiratory burst and intracellular free calcium][J]. Acta Pharmacologica Sinica, 1992, 13(4): 367-370 |
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| Authors: | X H Xin R L Bian |
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| Affiliation: | Department of Pharmacology, Zhejiang Medical University, Hangzhou, China. |
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| Abstract: | ![]()
The stimulatory effect of FMLP 5 nmol.L-1, OAG 25 nmol.L-1 and calcimycin 10 nmol.L-1 on luminol-dependent chemiluminescence (CL) was observed in human neutrophils (Neu). The rest level of Neu intracellular free calcium ([Ca]i) measured by Ca(2+)-sensitive probe Quin 2/AM was calculated to be 200 +/- s 19 nmol.L-1. By the addition of FMLP 0.1 nmol.L-1 or calcimycin 0.5 nmol.L-1, the peak [Ca]i increased to 769 +/- 104 nmol.L-1 and 953 +/- 53 nmol.L-1, respectively. Ketotifen (50-300 mumol.L-1) inhibited Neu CL in a dose-dependent manner with activator FMLP. Inhibition was also seen when Neu CL was activated by calcimycin and OAG, respectively. However, ketotifen did not inhibit Neu [Ca]i increment activated by FMLP and calcimycin. |
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