|
|||||
|
|
| 1,6-二磷酸果糖对心肌缺血/再灌注损伤保护作用的临床研究 | |
| 引用本文： | 刘建华,李李,王亚平,常业恬. 1,6-二磷酸果糖对心肌缺血/再灌注损伤保护作用的临床研究[J]. 中南大学学报(医学版), 1998, 0(5) |
| 作者姓名： | 刘建华 李李 王亚平 常业恬 |
| 作者单位： | 第二附属医院麻醉科 |
| 摘 要： | 将２０例简单室间隔缺损行体外循环手术病例均分为两组。实验组在体外循环预充液中一次性加入１，６－二磷酸果糖（ＦＤＰ）２００ｍｇ·ｋｇ－１，对照组不加。于主动脉插管时，开放主动脉后３０ｍｉｎ，６ｈ及２４ｈ抽桡动脉血测定血清乳酸脱氢酶、磷酸肌酸激酶和磷酸肌酸激酶心脏同功酶水平。结果表明，ＦＤＰ能降低体外循环术后乳酸脱氢酶、磷酸肌酸激酶和磷酸肌酸激酶心脏同功酶的上升幅度，提示ＦＤＰ可减轻体外循环心肌缺血／再灌注损伤 |
| 关 键 词： | 心肌再灌注损伤；1.6－二磷酸果糖；体外循环；心肌保护 |
Clinical study of fructose 1,6-diphosphate on myocardial ischemia/reperfusion injuries |
|
| Liu Jianghua Li Li Wang Yaping Chang Yetian. Clinical study of fructose 1,6-diphosphate on myocardial ischemia/reperfusion injuries[J]. Journal of Central South University. Medical sciences, 1998, 0(5) | |
| Authors: | Liu Jianghua Li Li Wang Yaping Chang Yetian |
| Abstract: | Twenty ventricular septal defect patients who underwent cardiopulmonary bypass (CPB) were divided into 1,6-diphosphate group and controlled group (10 cases each). Blood samples were taken at pre and post cardiopulmonary bypass 30min, 6h, and 24h to determine lactate dehydrogenase enzyme(LDH), creatine kinase enzyme(CK) and its isoenzyme(CK MB) levels. We found that 1,6 diphosphate decreased the increasing levels of LDH, CK, and CK MB after cardiopulmonary bypass. It is suggested that 1,6 diphosphate may attenuate myocardial ischemia/reperfusion injuries during cardiopulmonary bypass. |
| Keywords: | diphosphate myocardial reperfusion injuries myocardial protection * |
| 本文献已被 CNKI 等数据库收录！ | |