| 硝化甘油毒性研究 |
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| 引用本文： | 冯养正 张慧敏. 硝化甘油毒性研究[J]. 工业卫生与职业病, 1991, 17(4): 207-211 |
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| 作者姓名： | 冯养正 张慧敏 |
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| 作者单位： | 机械电子工业部工业卫生研究所，机械电子工业部工业卫生研究所，机械电子工业部工业卫生研究所，机械电子工业部工业卫生研究所 西安市南郊山门口 710061，西安市南郊山门口 710061，西安市南郊山门口 710061，西安市南郊山门口 710061 |
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| 摘 要： | 本文报道了硝化甘油的急性和亚慢性毒性。主要急性毒作用是对循环、中枢神经及血液系统的作用。大鼠及小鼠经口的LD50分别为428.4mg/kg和390.4mg/kg,小鼠腹腔注射LD50为252.5mg/kg。亚慢性毒性:200mg/kg剂量组12/14动物死亡,80及40mg/kg组出现明显中毒,20mg/kg组出现轻度中毒,中毒主要表现为高铁血红蛋白血症、睾丸组织萎缩及大剂量影响心脏舒缩功能。
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| 关 键 词： | 硝化甘油 毒性 工业毒理学 |
STUDY ON TOXICITY OF NITROGLYCERINE |
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| Feng Yangzheng et al. STUDY ON TOXICITY OF NITROGLYCERINE[J]. Industrial Health and Occupational Diseases, 1991, 17(4): 207-211 |
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| Authors: | Feng Yangzheng et al |
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| Abstract: | Acute and subchronic toxicities of nitroglycerine in rats and mice were reported.The main acute toxicity was effects on the circulation, blood and central nerve systems.Experiments showed that LD50 of rats and mice by ingestion were 428.4 mg/kg and 390.4 mg/kg respectively.LD50 of the mice by abdominal cavity injection were 252.5 mg/kg.In subchronic toxicity experiments, 12/14 of the animals were dead in 200 mg/kg group,severe intoxication happened in 80 mg/kg and 40 mg/kg group,and mild intoxication happened in 20mg/kg group. The main manifestations are methemoglobinemia, testis tissue atrophy and inhibition of the cardiac function. |
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| Keywords: | nitroglycerine acute toxicity subchronic toxicity |
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