加味桂枝甘草龙骨牡蛎汤治疗心胆气虚型失眠疗效观察

目的观察加味桂枝甘草龙骨牡蛎汤治疗心胆气虚型失眠的疗效。方法选取2017年10月—2019年4月闵行区中心医院收治的84例辨证符合心胆气虚型的失眠症患者作为研究对象,采用随机数字表法将其随机分为治疗组42例和对照组42例。对照组患者采用艾司唑仑片进行治疗,治疗组患者在此基础上采用加味桂枝甘草龙骨牡蛎汤进行治疗。比较两组患者治疗前后匹兹堡睡眠质量指数(PSQI)、睡眠状态自评量表(SRSS)评分、炎症因子水平以及治疗后的临床疗效。结果治疗后,治疗组心胆气虚型失眠患者PSQI各项评分及SRSS评分降低,且治疗组低于对照组,差异有统计学意义(P<0.05)。治疗组心胆气虚型失眠患者的睡眠改善总有效率88.23%优于对照组64.71%,差异有统计学意义(P<0.05)。治疗后,治疗组和对照组心胆气虚型失眠患者TNF-α和IL-6水平均显著降低,且治疗组低于对照组,差异有统计学意义(P<0.05)。结论加味桂枝甘草龙骨牡蛎汤可降低心胆气虚型失眠患者炎症反应,改善其睡眠质量,疗效确切。

Clinical observation on modified GuiZhi GanCao LongGu Muli Decoction in treating insomnia differentiated by heart-gallbladder qi deficiency

Objective To observe the effect of modified GuiZhi GanCao LongGu Muli Decoction in treating insomnia differentiated by heart-gallbladder qi deficiency pattern.Methods A total of 84 patients with insomnia differentiated by heart-gallbladder qi deficiency treated in Shanghai Minhang District Central Hospital from October,2017 to April,2019 were included and divided into a treatment group(42)and a control group(42)by using random number table.The control group was given estazolam tablets,and the treatment group was additionally given modified GuiZhi GanCao LongGu Muli Decoction based on the control group.The scores of Pittsburgh sleep quality index(PSQI),sleep state self-rating scale(SRSS),the levels of inflammatory factors,and clinical efficacy were compared between the two groups after treatment.Results After treatment,the scores of PSQI and SRSS in the treatment group decreased,which were significantly lower than in the control group,with statistical significance(P<0.05).The total effective rate of improvement of sleep quality in the treatment group(88.23%)was higher than in the control group(64.71%),with statistical significance(P<0.05).After treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in both groups decreased significantly,and the levels in the treatment group was lower than in the control group,with statistical significance(P<0.05).Conclusion Modified GuiZhi GanCao LongGu Muli Decoction can reduce the inflammatory response and improve sleep quality for patients with insomnia differentiated by heart-gallbladder qi deficiency pattern with a definite effect.