| 99mTc-MIBI显像评价乳腺癌新辅助化疗疗效及预后的价值 |
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| 引用本文： | 关晏星,雷秋模,熊秋云,杨晓青,张庆,张青,欧阳军,瞿伟.99mTc-MIBI显像评价乳腺癌新辅助化疗疗效及预后的价值[J].中华肿瘤防治杂志,2009,16(24):1935-1938. |
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| 作者姓名： | 关晏星 雷秋模 熊秋云 杨晓青 张庆 张青 欧阳军 瞿伟 |
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| 作者单位： | 1. 南昌大学第一附属医院核医学科,江西,南昌,330006
2. 南昌市第三医院乳腺外科,江西,南昌,330009 |
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| 摘 要： | 目的:探讨99mTc-MIBI显像评价乳腺癌新辅助化疗(NCT)疗效及预后的临床价值.方法:57例乳腺癌患者NCT前及Z个周期(30例)、3个周期(57例)NCT后分别行乳腺.99mTc-MIBI显像.肿瘤部位摄取采用靶和非靶比值(T/N)表示,术后行乳腺癌病理化疗反应分析.以NCT后T/N比值降低百分率>30%为判断化疗有效的闭值,将结果与病理检查结果对比,评价其诊断效能.根据该判断阈将患者分为显像有效组和无效组,进行临床随访,分析两组无进展生存时阃(PFS).结果:2个周期NCT后,99mTc-MIBI显像评价疗效的灵敏度、特异性和准确性分别为89%、83%和86%,阴性和阳性预测值分别为88%和83%,与对3个周期NCT疗效评价的效能差异无统计学意义,P>0.05.显像示有效组平均PFS为46.93个月,显像示无效组平均PFS为35.76个月,两组差异有统计学意义,P<0.05.结论:99mTc-MIBI显像对评价乳腺癌NCT反应、估计预后具有临床应用价值.
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| 关 键 词： | 乳腺肿瘤 放射性核素显像 甲氧基异丁基异腈 新辅助化疗 |
99mTc-MIBI imaging evaluates neoadjuvant chemotherapy effect and prognosis of patients with breast cancer |
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| GUAN Yan-xing,LEI Qiu-mo,XIONG Qiu-yun,YANG Xiao-qing,ZHANG Qing,ZHANG Qing,OUYANG Jun,QU Wei.99mTc-MIBI imaging evaluates neoadjuvant chemotherapy effect and prognosis of patients with breast cancer[J].Chinese Journal of Cancer Prevention and Treatment,2009,16(24):1935-1938. |
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| Authors: | GUAN Yan-xing LEI Qiu-mo XIONG Qiu-yun YANG Xiao-qing ZHANG Qing ZHANG Qing OUYANG Jun QU Wei |
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| Institution: | GUAN Yan-xing1,LEI Qiu-mo2,XIONG Qiu-yun2,YANG Xiao-qing1,ZHANG Qing1,OU YANG Jun1,QU Wei21.Department of Nuclear Medicine,First Affiliated Hospital of Nanchang University,Nanchang 330006,P.R.China2.Department of Mammary Tumor,Nanchang Third Hospital,Nanchang 330009,P.R.China |
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| Abstract: | OBJECTIVE:To investigate the value of 99mTc-MIBI imaging in evaluativing the response to neoadjuvant chemotherapy (NCT) and predicting the prognosis of patients with breast cancer. METHODS:99mTc-MIBI imaging for breast was performed in 57 patients with breast carcinoma before NCT and after 2 cycles(30 cases) or 3 cycles (57 cases)of NCT respectively. 99mTc -MIBI uptake in primary tumor was quantified by using the lesion-to-normal breast ratio (T/N ),The response of breast carcinoma to NCT was determined by ... |
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| Keywords: | breast neoplasms radionuclide imaging methoxyisobutylisonitrile neoadjuvant chemotherapy |
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