依那普利治疗慢性心衰的耐受性研究

目的：对慢性心衰患者,观察将依那普利5mg/d调整至20mg/d后的耐受性。方法：入组已服用依那普利5mg/d至少4周的慢性心衰患者,采用依那普利20mg/d治疗2个月,观察增量以后的安全性与耐受性。观察指标：不良事件和严重不良事件,患者依从性,记录基线状态、第4周、第8周血压、心率、血钾、肌酐和尿素氮。结果：共入选89例符合入选标准的慢性心衰患者,其中83例能够很好耐受依那普利,总耐受率为93.3%。共计13例患者（占14.6%）发生不良事件,无严重不良事件发生。结论：慢性心衰患者对依那普利20mg/d的治疗剂量耐受良好。

Studay on Drug Tolerance of Enalapril on Chronic Heart Failure

Objective: To evaluate the tolerability of enalapril dose-adjustment 5mg/d to 20mg/d in the patients with congestive heart failure.Method:Chosen patients with congestive heart failure who had received enalapril 5mg/d for at least 4 weeks,then given them enalapril 20mg/d for 2 months and observed the patients' safety and tolerability after the dose or enalapril had been increased to 20mg/d.Adverse events,blood pressure,heart rate,K+,Cr,BUN at baseline,week 4 and week 8 were recorded.Result: A total of 89 pat...