亚慢性镉中毒大鼠肾组织超微结构改变

目的 对亚慢性镉中毒大鼠的肾组织进行超微结构检查。方法 SD大鼠腹腔注射0.8mg·kg~(-1)·d~(-1)CdCl_2溶液(相当于0.8mgCd~(2+)),每周5次,共4周。取肾组织常规制片,透射电镜下观察。结果 镉中毒大鼠肾近曲小管上皮细胞、线粒体肿胀,嵴断裂,肾小球系膜细胞增生,足突间隙融合,鲍曼氏囊腔狭窄、毛细血管瘀血及间质纤维化,肾远曲小管上皮细胞肿胀、崩解,线粒体水肿、膜破裂。结论 亚慢性镉染毒除引起肾近曲小管上皮细胞出现超微结构病理改变外,对肾小球和肾远曲小管上皮细胞也产生严重损害。

Uhrastructural Changes In Kidneys Of Rats With Sub - chronic Cadmium Intoxication

[Objective]To make ultrastructural examination on renal tissues in rats with sub- chronic cadmium intoxication. [Methods]SD Rats were injected with 0.8 mg. Kg-1 .d - 1Cd DI2 (equals to 0.8mgDd2 + ) into abdominal cavity. Renal tissues were examined by transmission electron microscopy . [Results]Swollen cytoplasm and mitochondria as well as broken spinal were seen in proximal tubular lining cells. Mesangium cell hyperplasia, sub- podocytic space confluence, Bowman s capsule narrowing, capillary blood stasis, interstitial fibrosis occurred in renal glomeruli. In distal tubular lining cells, the cell swelled and disintegrated, mitochondria swelled and membrane broke down. [Conclusion] Sub- chronic cadmium exposure not only induced pathological ultrastructural changes in renal proximal tubular lining cells, but also exerted serious lesions on glomerulus and distal tubular lining cells.