初诊2型糖尿病合并代谢综合征患者治疗前后血清ghrelin水平的变化

目的 研究初诊2型糖尿病合并代谢综合征患者血浆血糖、血清胰岛素水平、血脂、胰岛β细胞功能及血清ghrelin水平的变化.方法 同步测定初诊2型糖尿病患者34例,其中合并代谢综合征(MS)患者15例治疗前、治疗后6个月静脉糖耐量试验(IVGTT)时血清、胰岛素、ghrelin、血浆血糖及三酰甘油(TG)、总胆固醇(TC)...

Effect of treatment on plasma ghrelin in patients with metabolic syndrome and newly diagnosed type 2 diabetes mellitus

Objective To investigate the relationship between the response of circulation plasma glucose,insulin,lipid levels and serum ghrelin to therapy and association between β-cell function with metabolic syndrome and newly diagnosed type 2 diabetes mellitus.Methods Total of 34 patients with newly diagnosed type 2 diabetes mellitus at three points was studied.At diagnose before treatment(DM0),after six months of treatment(DM2).Intravenous glucose tolerance tests(IVGTT) were performed,and blood glucose,HbA1C,insulin,ghrelin,total cholesterol,LDL-C,HDL-C and triglycerides were measured.Insulin sensitivity was assessed by homeostasis model assessment(HOMA).of the 34 patients,15 patients had metabolic syndrome.ResultsCompared with two different groups,beta-cell function was dramatically improved.The mean AUC of insulin was significantly increased after treatment(P<0.05),ghrelin levels and the mean AUC of ghrelin in DM0 groups were lower(P<0.05).Newly diagnosed type 2 diabetes mellitus with metabolic syndrome before treatment(ADM0) had higher levels of fasting serum ghrelin and insulin than did those without metabolic syndrome(BDM0)(P<0.05).Newly diagnosed type 2 diabetes mellitus with metabolic syndrome after treatment(ADM1) had lower levels of fasting serum ghrelin and insulin than did those without metabolic syndrome(BDM1)(P<0.05).Compared with ADM1 and BDM1,insulin levels and the mean AUCof insulin in BDM1 groups were lower(all P<0.05).Univariate linear regression analysis showed that fasting glucose(r=-0.274,P<0.05),fasting insulin(r=-0.276,P<0.05),and body mass index(r=-0.322,P<0.05) were negatively correlated with serum ghrelin,and serum high density lipoprotein HDL(r=0.367,P<0.05) was positively correlated with serum ghrelin.Conclusion Ghrelin might play an important role in the etiology and progress of metabolic syndrome and newly diagnosed type 2 diabetes mellitus.