| 结直肠癌患者P^53基因表达的研究 |
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| 引用本文： | 葛怀俊,周海滨,李真,楚浩.结直肠癌患者P^53基因表达的研究[J].中国民康医学,2005,17(4):134-134,161. |
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| 作者姓名： | 葛怀俊 周海滨 李真 楚浩 |
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| 作者单位： | 1. 山东省聊城市国际和平医院外一科,山东,聊城,252000
2. 华中科技大学同济医学院分生教研室 |
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| 摘 要： | 目的探讨结直肠癌患者与P53基因表达改变的相关性.方法用半定量逆转录PCR(RT-PCR)检测P53蛋白mRNA的表达水平,比较各组的差异.结果结直肠癌患者P53蛋白mRNA的表达水平从正常粘膜、癌旁组织、腺癌有逐渐降低的趋势,且正常粘膜组与腺癌组比较,差异具有显著性(P<0.05);结论结直肠癌患者与P53蛋白mRNA表达的降低有一定的相关性.
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| 关 键 词： | 结直肠癌 P^53蛋白 基因 |
| 文章编号： | 0369(2005)04-0134-02 |
Study of P53 gene expression in colorectal cancer |
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| GE Huai-jun,ZHOU Hai-bin,LI Zhen,et al.Study of P53 gene expression in colorectal cancer[J].medical journal of chinese peoples health,2005,17(4):134-134,161. |
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| Authors: | GE Huai-jun ZHOU Hai-bin LI Zhen |
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| Abstract: | Objective: To explore the relationship of the change of P 53 gene expression in colorectal cancer. Methods: Using RT-PCR to measure the level of mRNA of P 53 protein, compare the difference between with the colorectal group and the control group. Results: The level of mRNA of P 53 protein decreased more significantly in adenocarcinoma than in normal mucous membrane tissues (P<0.05). Conclusions: The change of expression of P 53 in tumor cells may be linking and promotion of colorectal cancer. |
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| Keywords: | Colorectal neoplasm Genes P 53 protein |
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