复合材料修复骨缺损血管化及结构特征变化

ThelecturesaboutcarriermaterialsofBMP（bonemorphogeneticprotein）areveryusual．ThecompoundmaterialscombinedwithBMPshouldhavefinemoldingability，biomechanicsandboneinductivecapability．Bonecementhasbeenusedwidespreadinartificialjointsurgery．WeusethecompoundmaterialofDBM（decalcifiedbonematrix）particleswhichwascombinedwithrhBMP－２（recombinedhumanbonemorphogeneticprotein）impregnatedwithbonecementtorepairtherabbitbonedefectandstudythechangesofcirculationandconstructionofthecompoundmateri…

Changes of circulation and construction on repairment of bone defect with compound material

Objective To observe the changes of circulation and construction by compound material of decalcified bone matrix (DBM) particles which was combined with rhBMP 2 impregnated with bone cement for repairment of experimental bone defect. Methods To assess the changes of circulation and construction, the methods of intravascular injection of India ink and scanning electron microscope were used. Results Results showed that an amount of regenerative blood vessels gathered around the implanted material and the blood vessels began to grow into it at the second week after operation, the blood vessels which grew into the implanted material increased gradually at the fourth, eighth and twelfth week after surgery. The changes of construction were observed that an amount of regenerative collagen was formed into the implanted material and the ossification developed from the collagen were seen in some places at the fourth week after implantation,a large amount of new bone which covered the DBM particles and the bone cement along the irregular gaps was found and the irregular gaps were filled up by the regenerative tissues in 8 to 12 weeks after operation. Conclusion The compound materials of DBM particles which were combined with rhBMP 2 impregnated with bone cement have favourable capacity of bone induction. This compound material can be used effectively to repair segmental bone defects.