| 凋亡机制异常导致的肿瘤耐药 |
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| 引用本文： | 赵曜. 凋亡机制异常导致的肿瘤耐药[J]. 国际肿瘤学杂志, 2010, 37(1). DOI: 10.3760/cma.j.issn.1673-422X.2010.01.009 |
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| 作者姓名： | 赵曜 |
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| 作者单位： | 上海交通大学附属第六人民医院骨科,200233 |
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| 摘 要： | 肿瘤耐药是导致肿瘤治疗失败的重要原因.近年研究发现,肿瘤细胞的死亡受体及线粒体凋亡途径均可表现多重的异常机制,并导致其对化疗耐药.深入了解肿瘤发生凋亡异常的机制,才能使针对性的抗癌治疗得到发展.针对凋亡变异机制设计的新药物,部分已上市或进入临床试验阶段.
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| 关 键 词： | 细胞凋亡 抗药性 肿瘤 基因疗法 |
Neoplasms chemoresistance induced by mutated mechanisms of apoptosis |
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| ZHAO Yao. Neoplasms chemoresistance induced by mutated mechanisms of apoptosis[J]. Journal of International Oncology, 2010, 37(1). DOI: 10.3760/cma.j.issn.1673-422X.2010.01.009 |
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| Authors: | ZHAO Yao |
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| Abstract: | Tumor chemoresistance can lead to chemotherapy failure.Research have identified multiple mutations in both the death receptor and mitochondrial apoptotic pathways,which result in tumor resistance to chemotherapy.Further understanding of the molecular mechanisms of abnormal apoptosis will facilitate the development of targeted tumor therapies.Novel drugs targeting the mutated apoptotic pathways are availble or in the clinic trial. |
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| Keywords: | Apoptosis Drug resistance,neoplasm Gene therapy |
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