| 消咳宁片质量标准研究 |
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| 引用本文： | 熊灿琼,吴娟.消咳宁片质量标准研究[J].中国药业,2010,19(6):23-24. |
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| 作者姓名： | 熊灿琼 吴娟 |
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| 作者单位： | 贵州省毕节地区药品检验所,贵州,毕节,551700 |
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| 摘 要： | 目的采用薄层色谱法鉴别消咳宁片中苦杏仁和甘草浸膏，建立测定盐酸麻黄碱含量的高效液相色谱法。方法色谱柱为Diamonsil C18柱（150mm×4．6mm，5μm），柱温为30℃，流动相为乙腈-0．1％磷酸溶液（9：88），检测波长为207nm。结果盐酸麻黄碱质量浓度在3．624-18．120μg／mL范围内与峰面积呈良好的线性关系，r=0．9998（n=5），平均回收率为99．24％，RSD=1．13％（n=9）。结论所建立的方法简单、快速、准确、重现性好，专属性更强。
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| 关 键 词： | 高效液相色谱法 盐酸麻黄碱 消咳宁片 |
Study of Quality Standard of Xiaokening Tablets |
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| Xiong Canqiong,Wu Juan.Study of Quality Standard of Xiaokening Tablets[J].China Pharmaceuticals,2010,19(6):23-24. |
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| Authors: | Xiong Canqiong Wu Juan |
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| Institution: | ( Bijie Institute for Drug Control, Bijie, Guizhou, China 551700) |
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| Abstract: | Objective To identify bitter almond and glycyrrhiza extract by TLC and to establish a HPLC method to determine ephedrin hydrochloride in Xiaokening Tablets. Methods The chromatographic column used in this HPLC method was Diamonsil C18 column（150mm×4.6mm,5μm）.The column temperature was 30℃ and the detective wavelength was 207 nm. The mobile phase was acetonitrile-0. 1% phosphoric acid （9：88）. Results The good linear relationship for ephedrine hydrochloride was found within the range of 3.624-18.120μg/mL, r = 0. 999 8 （n = 5）. The average recovery rate was 99.24%, RSD = 1.13% （n = 9）. Conclusion This method is simple, rapid and accurate with good reproducibility and strong specificity. |
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| Keywords: | HPLC ephedrin hydrochloride Xiaokening Tablets |
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