| Fas/FasL信号在免疫系统中的作用 |
| |
| 引用本文： | 赵亮,陈晓,郭振红. Fas/FasL信号在免疫系统中的作用[J]. 国际免疫学杂志, 2011, 34(1): 49-52. DOI: 10.3760/cma.j.issn.1673-4394.2011.01.013 |
| |
| 作者姓名： | 赵亮 陈晓 郭振红 |
| |
| 作者单位： | 第二军医大学附属长海医院学员大队本科生队,200433 |
| |
| 摘 要： | Fas/FasL通路是介导细胞凋亡的一条重要途径.近年来研究发现,它可以促进分泌炎症细胞因子,激发炎性反应,参与免疫豁免、免疫逃逸、肿瘤形成及转移等过程.此外,FasL还可以作为受体传递反向信号,促进细胞增殖,并参与一些自身免疫性疾病的发生.
|
| 关 键 词： | Fas/FasL 凋亡 炎症 反向信号 |
Roles of Fas/FasL signals in immune system |
| |
| ZHAO Liang,CHEN Xiao,GUO Zhen-hong. Roles of Fas/FasL signals in immune system[J]. International Journal of Immunology, 2011, 34(1): 49-52. DOI: 10.3760/cma.j.issn.1673-4394.2011.01.013 |
| |
| Authors: | ZHAO Liang CHEN Xiao GUO Zhen-hong |
| |
| Affiliation: | .( Second Military Medical University, Shanghai 200433, China) |
| |
| Abstract: | Fas/FasL mediates an important signal pathway cell apoptosis. Recent studies showed that it can stimulate the secretion of proinflammatory cytokines and induce inflammatory reaction. Inaddition, it also participates in a variety of biological activities such as immune privilege, immune escape and tumor formation and metastasis. FasL may also act as a receptor to deliver reverse signals, stimulating cell proliferation and paticipating in the development of some autoimmune diseases. |
| |
| Keywords: | Fas/FasL |
| 本文献已被 维普 万方数据 等数据库收录！ |
|
