| 抑癌基因KLF6的作用机制及其在相关肿瘤中的表达 |
| |
| 引用本文： | 张修稳,赵国海. 抑癌基因KLF6的作用机制及其在相关肿瘤中的表达[J]. 国际肿瘤学杂志, 2011, 38(2): 99-101. DOI: 10.3760/cma.j.issn.1673-422X.2011.02.006 |
| |
| 作者姓名： | 张修稳 赵国海 |
| |
| 作者单位： | 皖南医学院附属弋矶山医院胃肠外科,芜湖,241001 |
| |
| 摘 要： | KLF6的主要作用机制是以p53非依赖方式上调p21,进而导致细胞增殖的抑制,其表达异常或活性缺失与前列腺癌、肝癌、胃癌等多种肿瘤的发生发展及预后密切相关,并有可能成为分子靶向治疗的新靶点.
|
| 关 键 词： | 信号传导 基因表达 Kruppel样因子6 |
Mechanism and expression of KLF6 tumor suppressor gene in related tumors |
| |
| ZHANG Xiu-wen,ZHAO Guo-hai. Mechanism and expression of KLF6 tumor suppressor gene in related tumors[J]. Journal of International Oncology, 2011, 38(2): 99-101. DOI: 10.3760/cma.j.issn.1673-422X.2011.02.006 |
| |
| Authors: | ZHANG Xiu-wen ZHAO Guo-hai |
| |
| Abstract: | It has been revealed that the major mechanism of KLF6 is to upregulate p21 in an p53-independent manner leading to inhibition of cell proliferation. Lacking of KLF6 activity or its abnormal expression may be related to multiple tumors'development and prognosis such as prostate cancer, liver cancer, gastric cancer and other tumors. Furthermore, KLF6 may become a novel candidate for molecular target therapy. |
| |
| Keywords: | Signal transduction Gene expression Kruppel-like factor 6 |
| 本文献已被 万方数据 等数据库收录！ |
| 点击此处可从《国际肿瘤学杂志》浏览原始摘要信息 |
|
点击此处可从《国际肿瘤学杂志》下载全文 |
