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| P2X嘌呤受体在肠神经系统中的表达及功能 | |
| 引用本文： | 朱华,彭炜. P2X嘌呤受体在肠神经系统中的表达及功能[J]. 国际外科学杂志, 2011, 38(1): 37-40. DOI: 10.3760/cma.j.issn.1673-4203.2011.01.012 |
| 作者姓名： | 朱华 彭炜 |
| 作者单位： | 1. 蚌埠医学院,蚌埠,233030 2. 上海市中西医结合医院普外科,上海,200082 |
| 摘 要： | P2X受体为配体门控离子通道,细胞外ATP是其天然配体.当任何一种亚型的P2X受体与细胞外ATP结合时,P2X通道打开,允许阳离子(钙、钠、钾离子等)通过.肠神经系统(ENS)由肠道肌间神经丛和黏膜下神经丛组成,二者都存在P2X受体,它们在生理和病理情况下介导不同的效应.本文主要就肠神经系统内P2X受体的分布以及相关功... |
| 关 键 词： | ATP P2X受体 肠神经系统 |
Expression and function of P2X purine receptors in the enteric nervous system |
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| ZHU Hua,PENG Wei. Expression and function of P2X purine receptors in the enteric nervous system[J]. International Journal of Surgery, 2011, 38(1): 37-40. DOI: 10.3760/cma.j.issn.1673-4203.2011.01.012 | |
| Authors: | ZHU Hua PENG Wei |
| Abstract: | P2X receptors are ligand gated ion channels, extracellular ATP is their natural extracellular ligand. When any of the subtypes of P2X receptors and extracellular ATP are combined, P2X channel opens, allowing cations (calcium, sodium, potassium, etc. ) pass through. Enteric nervous system is composed of the gut myenteric plexus and submucosal plexus, in both of which P2X receptors exist, mediating different effects under physiological and pathological conditions. In this paper, the enteric nervous system,P2X receptor distribution and related functions are reviewed in order to further explore the P2X receptor in the diagnosis and treatment of intestinal diseases. |
| Keywords: | ATP |
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